Ehud Keinan 
Catalytic Antibodies 

Wenn man die kombinatorischen Mechanismen für die Biosynthese von Antikörpern sinnvoll einsetzt, kann eine quasi unbegrenzte Anzahl unterschiedlicher Biokatalysatoren erzeugt werden. Katalytische Antikörper sind in der Lage, beinahe jede Art chemischer Reaktion mit hoher Selektivität und Stereospezifität durchzuführen.
Die Pioniere des Einsatzes von katalytischen Antikörpern besprechen hier die gesamte Bandbreite dieses interdisziplinären Arbeitsfeldes mit Themen wie z. B.:

* theoretische Aspekte von Struktur, Mechanismus und Kinetik
* praktische Überlegungen von Techniken der Immunisierung bis zu Screening methoden
* in vitro Evolution und andere moderne Ansätze
* Anwendungsmöglichkeiten von der organischen Synthese bis in den medizinischen Bereich

Dies ist das erste Buch, das unter Mitarbeit der führenden Experten in Antikörper-Katalyse dieses Gebiet umfassend abdeckt, und dadurch eine unersetzliche Informationsquelle für Biochemiker, Organiker, Biotechnologen und Biomediziner darstellt.

Table of Content

Immunological Evolution of Catalysis
Critical Analysis of Antibody Catalysis
Theoretical Studies of Antibody Catalysis
The Enterprise of Catalytic Antibodies: A Historical Perspective
Catalytic Antibodies in Natural Products synthesis
Structure and Function of Catalytic Antibodies
Antibody Catalysis of Disfavored Chemical Reactions
Screening Methods for Catalytic Antibodies
In vitro Evolution of Catalytic Antibodies and Other Proteins via Combinatorial Libraries
Medicinal Potential of Catalytic Antibodies
Reactive Immunization: A Unique Approch to Aldolase Antibodies
The Antibody-catalyzed Water Oxidation Pathway
Antibody-catalyzed Photochemical Reactions
Selectivity with Catalytic Antibodies – What Can Be Achieved?
Catalytic Antibodies as Mechanistic and Structural Models of Hydrolytic Enzymes
Transition State Analogs – Archetype Antigens for Catalytic Antibody Generation
Polyclonal Catalytic Antibodies
Production of Monoclonal Catalytic Antibodies: Principles and Practice
Natural Catalytic Antibodies – Abzymes


With a Foreword by Richard Lerner (Scripps Institute)

About the author

Ehud Keinan is the Dean of the Faculty of Chemistry at the Technion – Israel Institute of Technology and Adjunct Professor at The Scripps Research Institute in La Jolla, California. He was born and educated in Israel, received his Ph.D. degree under Y. Mazur from the Weizmann Institute of Science and was a postdoctoral fellow under B.M. Trost at the University of Wisconsin. Professor Keinan, who holds the Benno Gitter Ilana Ben-Ami Chair of Biotechnology, was the founder and first Head of the Institute of Catalysis Science and Technology (ICST) in Israel. His list of awards includes the New England award for academic excellence, the Joseph and Madeleine Nash award, the Shannon award, the Cap Cure award, and the Herschel-Rich award for scientific excellence. He has published over 130 scientific papers and holds 15 patents in various fields, including biocatalysis with antibodies and enzymes, organic synthesis, organometallic chemistry, drug discovery, and molecular computing devices.