Glenn T. Clark & Raymond A. Dionne 
Orofacial Pain 
A Guide to Medications and Management

Orofacial Pain: A Guide to Medications and Management brings
together guidance and information on the rational use of
medications for the treatment of chronic orofacial pain. Focusing
on clinically relevant information throughout and aiming itself
squarely at the needs of dentists and other clinicians working
directly with orofacial pain, the book covers the use of oral,
injectable and topical medications for managing neuropathic and
musculoskeletal pain, headache, and uncommon orofacial pain
disorders. Useful features, such as discussion of the
top 60 medications prescribed for orofacial pain, are
integrated with comprehensive coverage of drug types, pharmacolegal
issues, and the interaction of medication management with other
treatment strategies.

Table of Content

Contributors v

Preface vii

Chapter 1: The 30 most prevalent chronic painful diseases, disorders, and dysfunctions that occur in the orofacial region 3
Glenn T. Clark, DDS, MS

Chapter 2: Top 60 most important medications used in an orofacial pain treatment center 29
Glenn T. Clark, DDS, MS

Chapter 3: Nonopioid analgesics, salicylates, NSAIDs, and corticosteroids for chronic pain 47
Raymond A. Dionne, DDS, Ph D and Glenn T. Clark, DDS, MS

Chapter 4: Opioids for chronic orofacial pain with a focus on nonmalignant chronic pain 66
Glenn T. Clark, DDS, MS and Steven H. Richeimer, MD

Chapter 5: Nocebo-responsive patients and topical pain control agents used for orofacial and mucosal pain 84
Glenn T. Clark, DDS, MS

Chapter 6: Anticonvulsant agents used for neuropathic pain including trigeminal neuralgia 95
Glenn T. Clark, DDS, MS and Antonia Teruel, DDS, MS, Ph D

Chapter 7: Skeletal muscle relaxants and antispasticity drugs for orofacial pain disorders 115
Glenn T. Clark, DDS, MS and Soma Sahai-Srivastava, MD

Chapter 8: Psychopharmacologic agents (antidepressants, antipsychotics, anxiolytics, and psychostimulants) used in chronic pain 129
Glenn T. Clark, DDS, MS, Mary A. Gutierrez, Pharm D, BCPP, Jaqueline S. Venturin, DDS and Steven H. Richeimer, MD

Chapter 9: Antibacterial agents as analgesics in chronic pain 145
Satish Kumar, DDS, MDSc, Glenn T. Clark, DDS, MS and Raymond A. Dionne, DDS, Ph D

Chapter 10: Using oral medications, infusions, and injections for differential diagnosis of orofacial pain 151
Saravanan Ram, DDS, MS, Satish Kumar, DDS, MDSc and Glenn T. Clark, DDS, MS

Chapter 11: Interventional therapy and injected agents for orofacial pain and spasm (including botulinum toxin) 164
Glenn T. Clark, DDS, MS and Alan Stiles, DMD

Chapter 12: Treatment for oral mucositis and noninfectious, non-neoplastic oral ulcerations 184
Satish Kumar, DDS, MDSc, Antonia Teruel, DDS, MS, Ph D and Glenn T. Clark, DDS, MS

Chapter 13: Management of orofacial pain and other co-morbidities in oropharyngeal and nasopharyngeal cancer patients 212
Saravanan Ram, DDS, MS and Glenn T. Clark, DDS, MS

Chapter 14: Burning mouth syndrome: an update on diagnosis and treatment methods 232
Piedad Suarez Durall, DDS and Glenn T. Clark, DDS, MS

Chapter 15: Headaches with a focus on chronic daily headache medications 248
Soma Sahai-Srivastava, MD and Glenn T. Clark, DDS, MS

Chapter 16: Differential diagnosis and management of masticatory myogenous pain and dysfunction 271
Glenn T. Clark, DDS, MS

Chapter 17: Diagnosing and managing chronic trigeminal neuropathy 295
Glenn T. Clark, DDS, MS

Chapter 18: Temporomandibular joint arthritis: implications, diagnosis, and management 311
Antonia Teruel, DDS, MS, Ph D, Jack S. Broussard, Jr., DDS and Glenn T. Clark, DDS, MS

Chapter 19: Five oral motor disorders: habitual tooth clenching and other involuntary oral motor disorders 326
Glenn T. Clark, DDS, MS and Saravanan Ram, DDS, MS

Chapter 20: Diagnosis and treatment of temporomandibular joint internal derangements 343
Glenn T. Clark, DDS, MS

Appendix: Drug list 356

Index 363

About the author

Glenn T. Clark, DDS, MS is Director of the Orofacial Pain and Oral Medicine Center at the University of Southern California Herman Ostrow School of Dentistry.

Raymond A. Dionne, DDS, Ph D is Scientific Director of the Division of Intramural Research at the National Institute of Nursing Research in Washington, DC.