James MacKillop & Harriet de Wit 
The Wiley-Blackwell Handbook of Addiction Psychopharmacology 

The Wiley-Blackwell Handbook of Addiction Psychopharmacologypresents a comprehensive guide to contemporary research approachesto the study of drug addiction in adults. With a focus onempirically relevant research methods and nuanced methodologies, itprovides practical tools to enable strong psychopharmacologicalpractices. Contributions from experts in diverse domains offerreviews of the most current experimental methodologies, makerecommendations for ‘best-practices’, and identify futuredirections for the field. Topics covered include core methods forassessing drug effects, distal and proximal determinants of druguse, and insights from cognitive neuroscience.

Compiled by a team of widely-published researchers in substanceaddiction, the Wiley-Blackwell Handbook of Addiction Psychopharmacology is an authoritative, state-of-the-artcollection of modern research approaches for the scientific studyof drug addiction. Its multidisciplinary approach makes it acomprehensive and invaluable resource for all those in thisfield

Table of Content

About the Editors xi

About the Contributors xiii

Introduction: The Science of Addiction Psychopharmacology 1
James Mac Killop & Harriet de Wit

Part I Distal Determinants of Drug Use 5

1 Developmental Factors in Addiction: Methodological Considerations 7
Laurie Chassin, Clark Presson, Young Il-Cho, Matthew Lee, and Jonathan Macy

2 Executive Dysfunction in Addiction 27
David P. Jarmolowicz, E. Terry Mueller, Mikhail N. Koffarnus, Anne E. Carter, Kirstin M. Gatchalian, and Warren K. Bickel

3 The Roles of Race and Sex in Addiction Research 63
Ezemenari M. Obasi, Jaime L. Richards, Delishia M. Pittman, Jokae Ingram, Marian R. Beasley, and Kristen L. Ratliff

4 Understanding Psychiatric Comorbidities and Addictions 83
James C. (Jim) Anthony

5 Personality and Addiction: A Critical Review of Assessment Approaches 111
Joshua D. Miller and Donald R. Lynam

6 Behavioral Inhibition and Addiction 135
Mark T. Fillmore and Jessica Weafer

7 Delay Discounting and Drug Abuse: Empirical, Conceptual, and Methodological Considerations 165
Jeffrey S. Stein and Gregory J. Madden

8 Assessment of Risk Taking in Addiction Research 209
Jennifer Dahne, Jessica M. Richards, Monique Ernst, Laura Mac Pherson, and Carl W. Lejuez

9 Distress Tolerance 233
Jessica F. Magidson, Bina Ali, Alyson Listhaus, and Stacey B. Daughters

Part II Proximal Determinants of Drug Use 257

10 Measuring Direct Effects of Drugs of Abuse in Humans 259
Harriet de Wit

11 The Role of Aftereffects and Withdrawal in Addiction 281
Jon D. Kassel, Jennifer C. Veilleux, Adrienne J. Heinz, Ashley Braun, and Stefanie Weber

12 Drug Self-Administration Paradigms: Methods for Quantifying Motivation in Experimental Research 315
James Mac Killop and Cara Murphy

13 The Assessment of Craving in Addiction Research 345
Lara A. Ray, Kelly E. Courtney, Guadalupe Bacio, and James Mac Killop

14 The Cue Reactivity Paradigm in Addiction Research 381
Elizabeth K. Reynolds and Peter M. Monti

15 Stress and Affective Inductions in Addiction Research 411
Suzanne Thomas and Amy Bacon

16 Substance Priming 435
Abigail K. Rose

17 Understanding the Role of Substance Expectancies in Addiction 459
Jane Metrik and Damaris J. Rohsenow

18 Implicit Cognition 489
Paul Christiansen and Matt Field

19 Experimental Methods for Understanding the Role of Social Context in Drug Addiction 515
Matthew G. Kirkpatrick and Margaret C. Wardle

20 Ecological Momentary Assessment 541
Thomas R. Kirchner and Saul Shiffman

Part III Insights from Cognitive Science 567

21 Startle Reflex and Psychophysiology 569
Jeffrey C. Meehan and Robert Miranda, Jr

22 Using Quantitative EEG and EEG Tomography to Understand Drug Abuse: A Quantum Leap in New Methods and Benefits 599
David G. Gilbert and Herman A. Diggs

23 Functional Magnetic Resonance Imaging in Addiction Research 643
Lawrence H. Sweet, Michael T. Amlung, and James Mac Killop

24 The Role of Positron Emission Imaging (PET) in Understanding Addiction 677
Dean F. Wong, James Robert Brasic, Emily Gean, and Ayon Nandi

25 Application of Magnetic Resonance Spectroscopic Imaging to Addiction Research 707
Sujung Yoon, In Kyoon Lyoo, and Perry F. Renshaw

Conclusions: Consilience as the Future of Addiction Psychopharmacology 751
James Mac Killop & Harriet de Wit

Index 755

Plate section between 688 and 689

About the author

James Mac Killop is Associate Professor, Department of Psychology, University of Georgia; and Adjunct Associate Professor, Department of Behavioral and Social Sciences, Brown University. Dr.Mac Killop’s research has been supported by the National Institutesof Health, the Robert Wood Johnson Foundation, and the Alcoholic Medical Research Foundation, among other granting agencies, and hehas published over 70 peer-reviewed articles and book chapters inthis area.

Harriet de Wit is Professor, Department of Psychiatry and Behavioral Neuroscience, University of Chicago. Dr. de Wit haspublished over 200 empirical papers and is an editor of thejournals Psychopharmacology and Alcoholism: Clinical and Experimental Research.