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This new Springer volume, which comes complete with a free DVD, is a comprehensive and detailed overview of the synapse with emphasis on the glutamatergic synapse. Most chapters relate the synapse’s functional aspects to its molecular mechanisms. This approach shows which mechanisms are characterized on both the functional and structural level and can thus be considered firmly established. It’s an important text for neuroscientists and disease-oriented clinicians in neurology.
€149.79
Table of Content
Diversity in Synapse Structure and Composition.- The Role of Glutamate Transporters in Synaptic Transmission.- Structure and Function of Vertebrate and Invertebrate Active Zones.- Neurotransmitter Release Machinery: Components of the Neuronal SNARE Complex and Their Function.- The Molecular Machinery for Synaptic Vesicle Endocytosis.- Initiation and Regulation of Synaptic Transmission by Presynaptic Calcium Channel Signaling Complexes.- Adhesion Molecules at the Synapse.- Dendritic Organelles for Postsynaptic Trafficking.- Structure and Mechanism of Action of AMPA and Kainate Receptors.- Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity.- Structure and Function of the NMDA Receptor.- Molecular Properties and Cell Biology of the NMDA Receptor.- Surface Trafficking of Membrane Proteins at Excitatory and Inhibitory Synapses.- Scaffold Proteins in the Postsynaptic Density.- Ca2+ Signaling in Dendritic Spines.- Postsynaptic Targeting of Protein Kinases and Phosphatases.- Long-Term Potentiation.- Homeostatic Synaptic Plasticity.- Ubiquitin and Protein Degradation in Synapse Function.- Signaling from Synapse to Nucleus.- Molecular Organization of the Postsynaptic Membrane at Inhibitory Synapses.- Acid-Sensing Ion Channels (ASICs) and p H in Synapse Physiology.- Glia as Active Participants in the Development and Function of Synapses.- Plasticity of Dentate Granule Cell Mossy Fiber Synapses: A Putative Mechanism of Limbic Epileptogenesis.- Stroke – A Synaptic Perspective.- and Pathological Pain.
Language English ● Format PDF ● Pages 801 ● ISBN 9780387772325 ● File size 73.3 MB ● Editor Johannes W. Hell & Michael D. Ehlers ● Publisher Springer US ● City NY ● Country US ● Published 2008 ● Downloadable 24 months ● Currency EUR ● ID 2146122 ● Copy protection Adobe DRM
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