Nils Erik Gilhus & Michael R. Barnes 
European Handbook of Neurological Management, Volume 1 

Evidence-based, peer reviewed, best practice management
guidelines for neurologists

Diagnosis is only part of the puzzle. Effective treatment is
what your patients really want. The European Federation of
Neurological Societies has been publishing management guidelines in
the European Journal of Neurology for many years. Developed
by a consensus approach, using graded evidence, and then fully peer
reviewed, these guidelines provide gold-standard, best-practice
guidance to the treatment of neurological disorders. They help
bridge the gap between what is done and what should be done for
patients with neurological disorders.

The basic guidelines have been expanded with
‘Recommendations’ based on strong evidence and
‘Good Practice Points’ where only weaker evidence is
available. The Guidelines in this volume cover:

Investigation

Major neurological diseases

Neuromuscular diseases

Infections

Neurological problems

Sleep disorders

Rehabilitation

The European Handbook of Neurological Management provides
a thoroughly rounded and grounded approach to best-practice
neurological management using evidence-based principles.

Table of Content

Introduction.

Section 1 Investigations.

1 Routine cerebrospinal fluid (CSF) analysis.

2 Use of imaging in cerebrovascular disease.

3 Use of imaging in multiple sclerosis.

4 Neurophysiological tests and neuroimaging procedures in
non-acute headache.

5 Use of anti-interferon beta antibody measurements in multiple
sclerosis.

6 Use of antibody testing in nervous system disorders.

7 Use of skin biopsy in the diagnosis of small fibre
neuropathy.

8 Assessment of neuropathic pain.

Section 2 Major Neurological Diseases.

9 Ischaemic stroke and transient ischaemic attack.

10 Drug treatment of migraine.

11 Cluster headache and other trigemino-autonomic
cephalgias.

12 Diagnosis and treatment of primary (idiopathic) dystonia.

13 Mild traumatic brain injury.

14 Early (uncomplicated) Parkinson’s disease.

15 Late (complicated) Parkinson’s disease.

16 Alzheimer’s disease.

Section 3 Neuromuscular Diseases.

17 Management of amyotrophic lateral sclerosis.

18 Post-polio syndrome.

19 Autoimmune neuromuscular transmission disorders.

20 Chronic infl ammatory demyelinating
polyradiculoneuropathy.

21 Multifocal motor neuropathy.

22 Paraproteinaemic demyelinating neuropathies.

23 Limb girdle muscular dystrophies.

Section 4 Infections.

24 Neurological complications of HIV infection.

25 Viral meningo-encephalitis.

Section 5 Neurological Problems.

26 Treatment of neuropathic pain.

27 Acute relapses of multiple sclerosis.

28 Status epilepticus.

29 Alcohol-related seizures.

30 Brain metastases.

31 Paraneoplastic neurological syndromes.

32 Nystagmus and oscillopsia.

33 Orthostatic hypotension.

34 Cerebral venous and sinus thrombosis.

35 Cerebral vasculitis.

36 Neurological problems in liver transplantation.

37 Fatty acid mitochondrial disorders.

Section 6 Sleep Disorders.

38 Management of narcolepsy in adults.

39 Sleep disorders in neurodegenerative disorders and
stroke.

Section 7 Rehabilitation.

40 Cognitive rehabilitation.

Index.

About the author

Nils Erik Gilhus, MD, University of Bergen, Norway

Michael Brainin, MD, Danube University Krems, Austria

Michael Barnes, MD FRCP, University of Newcastle, UK