Table of Content
Guest editorial: Professor Sir Bruce Ponder (AGREED)
1. Epidemiology: public health burden, increasing disease and/or increasing detection, lag phase, risk factors ? Prof. John Potter Fred Hutchinson Centre/? Paul Pharoah
2. Pathogenesis:
– cancer stem cells: Prof. Sir Nick Wright, London Research Institute
– inflammation: Lisa Coussens, University California San Francisco
– hereditary factors: Paul Pharoah/Bruce Ponder CRI, Cambridge
– acquired mutations: Doug Hanahan /Robert Weinberg, University California San Francisco
– Epigenetics: E.G. William Nelson Baltimore/ Steve Meltzer John Hopkins USA
3. Animal models and other model systems of pre-invasive disease e.g. Tyler Jacks MIT or Dave Tuveson, CRI cambridge
4. Biomarkers – tissue, serum, fluids: Prof. Brian Reid, Fred Hutchinson Cancer Center, Seattle or Barbara Weber, GSK Pharmaceuticals
5. Molecular imaging: Professor Kevin Brindle Cambridge Research Institute, UK or Gary Kelloff NCI, Rockville
6. Issues around screening/surveillance: psychosocial, economic: Dr. Dawn Provenzale Duke University/ Karen Basen-Engquist MD Anderson texas/ prof Jane Blazeby Bristol UK
7. Disease specific examples:
Lung: Herman Baltimore
Mouth: Miriam Rosin Vancouver
Oesophagus: Dr Rebecca Fitzgerald, Cambridge UK
Stomach: Dr. Tim Wang, Columbia Univ, New York
Colon: Prof Bert Vogelstein, John Hopkins USA, John Potter, Seattle
Breast: Prof Stephen Duffty, CRUK, UK
Cervix –papsmear/vaccines: TC Wu, Johns Hokins Baltimore
Prostate/bladder: Professor David Neal, CRI Cambridge
8. Chemoprevention: e.g. Prof. John Potter Fred Hutchinson Centre
9. Treatment of early lesions: Jacques Van Dam Stanford / or Jacques Bergman Amsterdam
10. Common threads: areas for future research and future costs.benefits to society for early detection: or Michael Sporn Dartmouth Med Sch New Hampshire, or Gary Kelloff NCI, Maryland or Prof. George Triadafilopoulos, Stanford