Robert Crichton & Roberta Ward 
Metal-Based Neurodegeneration 
From Molecular Mechanisms to Therapeutic Strategies

Neurodegenerative diseases of the human brain appear in various
forms, resulting in disorders of movement and coordination,
cognitive deterioration and psychiatric disturbances. Many of the
key factors leading to neurodegenerative diseases are similar,
including the dysfunction of metal ion homeostasis, redox-active
metal ions generating oxidative stress, and intracellular inclusion
bodies.

Metal-based Neurodegeneration presents a detailed survey
of the molecular origins of neurodegenerative diseases. Each
chapter is dedicated to a specific disease, presenting the latest
scientific findings, including details of their biochemical
actors (proteins or peptides), their normal and pathological
conformations, and a description of the diseases characteristics,
with an emphasis on the role of metal-induced oxidative stress,
which can result in the production of intracellular aggregates of
target proteins and peptides.

Topics covered include:

* Brain function, physiology and the blood-brain barrier

* Immune system and neuroinflammation

* Aging and mild cognitive impairment, MCI

* Parkinson’s Disease

* Alzheimer’s Disease

* Creutzfelt-Jakob and related prion diseases

* Alcoholic Brain Damage

* Therapeutic strategies to combat the onset and progression of
neurological diseases

This extensively updated, full colour, second edition of
Metal-based Neurodegeneration is an essential text for
research scientists and clinicians working in gerontology,
neuropathology, neurochemistry, and metalloprotein mechanisms.

About the author

Robert Crichton and Roberta Ward,

Unit of Biochemistry, Université Catholique de Louvain,
Belgium