Christoph Wagener & Carol Stocking 
Cancer Signaling 
From Molecular Biology to Targeted Therapy

Dieses verständlich geschriebene Lehrbuch vermittelt alles Wissenswerte rund um die molekulare Onkologie. Vor allem die bei vielen Krebsarten wichtigen Signalwege werden detailliert dargestellt. Eine Vielzahl von Lehrvideos machen das Thema erfahrbar.

Table of Content

General Aspects of Signal Transduction and Cancer Therapy
Tumor Cell Heterogeneity and Resistance to Targeted Therapy
Cell Cycle of Tumor Cells
Cell Aging and Cell Death
Growth Factors and Receptor Tyrosine Kinases
The Philadelphia Chromosome and BCR-ABL1
MAPK Signaling
PI3K-AKT-m TOR Signaling
Hypoxia-Inducible Factor (HIF)
NF-kappa B Pathways
Wnt Signaling
Notch Signaling
Hedgehog Signaling
TGFbeta Signaling

About the author

Christoph Wagener is Professor of Clinical Biochemistry and former director of the Institute of Clinical Chemistry at the University Medical Center Hamburg-Eppendorf, Germany. His areas of research are the interaction of tumor cells with their microenvironment, and molecular approaches to tumor diagnosis. Professor Wagener has authored more than 100 original scientific publications, 15 scientific reviews and 13 book chapters. Together with Oliver Müller, he published the text book ‘Molekulare Onkologie’ and the ‘Onkoview Videos’, which can be viewed on You Tube. Book and videos have received excellent reviews from readers and viewers.

Carol Stocking is Head of the Research Group Retroviral Pathogenesis at the Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology in Hamburg, Germany. She is a highly regarded expert in the field of leukemogenesis and hematology. Her areas of research are gene regulation, molecular control of differentiation, and hematopoietic stem cells. Dr. Stocking has authored more than 120 original publications in top international journals and 20 book chapters.

Oliver Müller is Professor for Applied Life Sciences at the University for Applied Sciences Kaiserslautern, Germany. He holds academic degrees in both biochemistry and medicine. His areas of research are the intracellular signal transduction and the genes and proteins involved in carcinogenesis. Professor Müller is author of more than 80 original articles, 11 patents, 15 scientific reviews and 4 book chapters. His work was honoured by several science awards.