Kewal K. Jain 
Drug-induced Neurological Disorders 

This book is a first-of-its kind reference that systematically organizes and describes the adverse effects of drugs on the nervous system. Drug safety is recognized as an important aspect of pharmaceutical companies as well as practice of medicine. 






Chapters include case reports of adverse effects of drugs that are published as well as reported to drug manufacturers. The book scope is broad as it covers lack of efficacy, drug resistance, drug-disease and drug-drug interactions. This information is used to improve the use of drugs as well as to design better and safer drugs for the future, and is relevant to personalized medicine in trying to match the right drugs to the patients.






Drug-induced Neurological Disorders offers a unique approach to this important topic by integrating clinical neurology with pharmacology with a focus on effects of drugs on the nervous system including those used for the treatment of neurological disorders as well systemic diseases. Many adverse effects involve multiple systems of the body and the syndromes with predominant effect on the nervous system are included in this book.

Table of Content

​Part I: Basic Aspects

Foreword to the First Edition, 1996, Prof. Walter Bradley (attached)


Preface to the 4th edition


1. Introduction, Definitions and Historical Aspects of Drug-induced Neurological Disorders


2. Epidemiology of Drug-induced Neurological Disorders and their Clinical Significance 


3. Role of the Blood-Brain Barrier in Effects of Drugs on the Brain


4. Neurotoxicity


5. Pathomechanisms of Drug-induced Neurological Disorders


6. Drug Addiction


7. Adverse effects of Drugs on the Fetal Brain


Part II: Drug-induced Diseases and Syndromes


8. Drug-induced Encephalopathies 


9. Drug-induced Disorders of Memory and Cognition


10. Drug-induced Disturbances of Consciousness


11. Drug-induced Sleep Disorders


12. Drug-induced Neuropsychiatric Disorders


13. Drug-induced Headaches


14. Drug-induced Seizures 


15. Drug-induced Movement Disorders 


16. Drug-induced Cerebrovascular Disorders 


17. Drug-induced Disorders of Cranial Nerves/Special Senses


18. Drug-induced Peripheral Neuropathies 


19. Neuromuscular Disorders 


20. Drug-induced Myopathies 


21. Drug-induced Spinal Disorders 


22. Drug-induced Cerebellar Disorders 


23. Drug-induced Aseptic Meninigitis 


24. Drug-induced Intracranial Hypertension


25. Drug-induced Disorders of the Autonomic Nervous System 


26. Eosinophilia-Myalgia Syndrome 


27. Serotonin Syndrome 


28. Drug-induced Guillain-Barré Syndrome 


29. Neuroleptic Malignant Syndrome 


30. Subacute Myelo-Optico-Neuropathy 


31. Drug-induced Neuroendocrine Disorders


32. Drug-induced Pituitary Disorders


Part III: Neurological Complications of Therapies


33. Neurological Complications of Cancer Therapies


34. Adverse Effects of new Biotechnologies on The Nervous System


35. Adverse Effects of Biological Therapies on The Nervous System


36. Neurological Complications of Cell Therapy


37. Neurological Complications of Gene Therapy


38. Adverse Effects of Vaccines on The Nervous System


39. Neurological Complications of Anesthesia


40. Outlook for Safer Therapies, Personalized Neurology, Targeted Drug Delivery and Prevention of Adverse Effects on the Nervous System

About the author

​Prof. K. K. Jain MD, FRACS, FFPM

Consultant in Neurology


CEO, Jain Pharma Biotech


Blaesiring 7


CH-4057 Basel, Switzerland