From the introduction: “The purpose of the present book is to bring together in a coherent manner new knowledge gained from research over the past 50 years on the physiology of intraocular pressure, ocular blood flow and the relation of these fundamental parameters to early diagnosis and therapy of vascular diseases of the eye and brain. It will be evident to the reader that the presentation is influenced significantly by the author’s own research. My justification is that by good fortune I have spent many years with superb collaboration helping solve outstanding problems of ocular physiology. This knowledge has increased understanding of the parameters underlying the onset of ischemia and the loss of autoregulation associated with common ocular disease and thereby led to new methods of diagnosis and therapy.”
Table of ContentInvasive Studies of the Parameters Regulating Ocular Physiology and Vision.- “In Vivo” Manometric Studies of the Steady State Intraocular Pressure and the Intraocular Pressure Pulse in Animals and Man.- The Rate of Formation of the Aqueous Humor.- The Steady State Intraocular Pressure/Flow Relations in Dead and Living Animal and Human Eyes.- Homeostasis, Autoregulation, and Relative Ischemia.- The Pressure/Volume Relation in Eyes of Dead and Living Animal and Human Eyes.- The Ocular Perfusion Pressure and Its Influence on the Intraocular Pressure Pulse.- Direct and Indirect Measurements of Ocular Blood Flow in Anesthetized and Conscious Animals and Humans.- The Morphology and Hydrodynamics of the Chamber Angle Draining the Aqueous Humor.- The Sympathetic Nerve Innervation of the Eye and the Actions of the Adrenergic Neuron Transmitter Norepinephrine on Intraocular Pressure and Ocular Blood Flow.- Manometric Studies ?on the Intraocular Pressure and Vascular Circulation in Ophthalmic Disease.- Noninvasive Studies on the IOP, PA, and Blood Flow Autoregulation in Healthy and Diseased Eyes.- Indirect Measurements of the Intraocular Pressure and the Intraocular Pressure Pulse.- The Effect of Posture and Corneal Thickness on the Measurement of the Intraocular Pressure.- The Langham Pneumatic Analogue and Digitized Tonometers.- The Calibration of the Intraocular Pressure and the Intraocular Pressure Pulse using the Langham Pneumatic Tonometer.- The Theory of the Langham Tonometer.- The Intraocular Pressure/Pulse Amplitude Relation in Healthy Animal and Human Eyes.- The Intraocular Pressure/Pulse Amplitude Relation and Loss of Autoregulation in Ocular Diseases.- Autoregulation of the Intraocular Pressure and the Ocular Blood Flow.- The Evaluation of Ocular Ischemia and the Loss of Autoregulation for the Early Detection of Ocular Vascular Diseases.- The Action of Drugs on Ocular Blood Flow and on the Intraocular Pressure/Pulse Amplitude Relation.- The Confluence and Integration of Therapies Based on Modulation of the Intraocular Pressure and Ocular Blood Flow.- Longitudinal Therapeutic Studies.- Opthalmodynamometry, the Ophthalmic Arterial Pressure and the Effect of Increased Vascular Resistance Proximal and Distal to the Ophthalmic Artery on Ocular Blood Flow, the IOP/PA Relation and Vision.- The Ophthalmic Arterial Pressure, the Intraocular Pressure/Pulse Amplitude Curve, and Their Relations to the Ocular and Cerebral Circulations.- Ophthalmodynamometry.- Autoregulation of the Intraocular Pressure and Blood Flow in the Human Eye.- Objective Measurement of the Diastolic and Systolic Ophthalmic Arterial Pressures.- The Ophthalmic Arterial Pressure in Healthy Subjects.- The Relation Between the Ophthalmic Arterial Pressure and the Intraocular Pressure/Pulse Amplitude Relation.- Modulation of the Intraocular Pressure/Pulse Amplitude Relation in Subjects with Stenosis of the Internal Carotid Artery.- Alzheimer’s Disease and the Eye.- The Ocular Perfusion Pressure and the Visual Threshold.- Concepts and New Perspectives.