A Jalila Simaan & Marius Réglier 
COPPER BIOINORGANIC CHEMISTRY 
From Health to Bioinspired Catalysis

Bioinorganic chemistry is an interdisciplinary research field which centers on metals in biology. Over the past few decades, advances in chemistry, biology as well as in spectroscopic methods have shed light on the role of copper in human pathologies and allowed the growing discovery of copper-containing biological systems. Following this trend, much effort is being constantly chanelled towards understanding these fundamental biological processes or enzymes. In addition, chemists are developing molecules to target copper or copper enzymes as therapeutic tools. On the other hand, inspired by the function of biological systems, small molecular weight complexes inspired by the active site of copper enzymes are being prepared and studied. These bioinspired complexes can function both as mechanistic tools and as functional catalysts for oxidative transformations.

The seven chapters in this book, contributed by internationally recognized authors cover recent developments on these aspects illustrated by interdisciplinary fields from biology, chemistry, spectroscopy to bioinspired catalysis. It contains aspects ranging from human health issues (copper homeostasis in bacteria and the development of molecules as anticancer or antibacterial agents) to bioinspired catalysis.

Contents:

• Ligands as a Tool to Tune the Toxicity of Cu on Bacteria: From Boosting to Silencing (Lisa Zuily, Nora Lahrach, Enrico Falcone, Merwan Bouraguba, Vincent Lebrun, Elisabeth Lojou, Marie-Thérèse Giudici-Orticoni, Peter Faller, and Marianne Ilbert)


• Transition State Analogue Molecules as Mechanistic Tools and Inhibitors for Tyrosinase (Clarisse Faure, Amaury du Moulinet d’Hardemare, Hélène Jamet, Catherine Belle, Elisabetta Bergantino, Luigi Bubacco, Maurizio Benfatto, A Jalila Simaan, and Marius Réglier)


• Modeling Tyrosinase Activity Using m-Xylyl-Based Ligands: Ring Hydroxylation, Reactivity, and Theoretical Investigation (Puneet Gupta and Rabindranath Mukherjee)


• Monooxygenation of Phenols by Small-molecule Models of Tyrosinase: Correlations Between Structure and Catalytic Activity (Alexander Koch, Tobias A Engesser, Ramona Jurgeleit, and Felix Tuczek)


• Electrochemistry and Spectroelectrochemistry of Copper-Oxygen-Relevant Species (Nicolas Le Poul)


• Inorganic Models of Lytic Polysaccharide Monooxygenases (Ivan Castillo)


• Structure and Function of Cu-Peptoid Complexes (Anastasia E Behar, Pritam Ghosh, and Galia Maayan)

Readership: Masters students, graduate students and researchers in copper bioinorganic chemistry and biological chemistry.

Key Features:

• The last book about copper bioinorganic chemistry was published in 1993


• Copper bioinorganic chemistry is gaining recent attention since the discovery of its implication in human pathologies and of new copper-containing systems


• This book was decided after the international conference on copper bioinorganic chemistry that was held in Marseille in 2018 (Cu BICS) and that gathered the main contributors in the field


• It contains aspects ranging from human health issues (copper homeostasis in bacteria and the development of molecules as anticancer or antibacterial agents) to bioinspired catalysis