Molecular Pathology of Neoplastic Gastrointestinal Diseases reviews the molecular aspects that characterize the spectrum of neoplastic conditions that affect the gastrointestinal tract, providing the reader with current up-to-date knowledge. For each disease entity chapters provide reviews on:
- the molecular basis of the individual disease
- molecular testing approaches currently available or in development for diagnosis or for gene target characterization for selective targeted therapies
- recommended guidelines for clinical application of molecular tests are included whenever available
- molecular testing for hereditary predisposition or disease risk
- animal models and cell culture models of disease
Table of Content
Section 1. Introduction.- 1. Mechanisms of Gastrointestinal Carcinogenesis.- Section 2. Epithelial Neoplastic Disease.- 2. Targeted Therapies and Molecular Diagnostics of Gastrointestinal Cancers.- 3. Molecular Pathology of Barrett’s Metaplasia and Esophageal Adenocarcinoma.- 4. Molecular Pathology of Squamous Carcinomas of the Esophagus.- 5. Molecular Mechanisms and Pathology of Gastric Carcinogenesis: Sporadic Cancers.- 6. Hereditary Diffuse Gastric Cancer and Other Gastric Cancers Associated with Hereditary Predisposition Syndromes.- 7. Cancer Predisposition Syndromes of the Gastrointestinal Tract.- 8. Molecular Pathology of Colon and Small Bowel Cancers: Sporadic Types.- 9. Cancers of the Rectum and Anal Canal.- 10. Molecular Pathology of Inflammatory Bowel Disease Associated Neoplasia.- Section 3. Non-Epithelial Neoplastic Tumors.- 11. Molecular Biology and Pathology of Gastrointestinal Stromal Tumors.- 12. Neuroendocrine Tumors .- Section 4. Metastatic Disease and Tumor Markers.- 13. Molecular Mechanisms of Tumor Metastases.- 14. Circulating Tumor Cells and Nucleic Acids for Tumor Diagnosis.- 15. Serological Markers of Digestive Tract Cancers.
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