Obesity is a worldwide epidemic that affects half a billion people. It has been estimated that, if current trends continue, by 2050, 60% of men and 50% of women worldwide will be obese. Hypertrophy and hyperplasia of white adipose tissue caused by overweight and obesity lead to a chronic inflammatory state, which results in impaired insulin sensitivity and the development of diabetes. Currently, the number of people affected by diabetes globally exceeds 400 million (rising more rapidly in low- and middle-income countries). In 2019, diabetes was the ninth leading cause of mortality, with an estimated 1.5 million direct deaths.
This book provides a comprehensive overview of the relationship between inflammation, obesity, and diabetes. It focuses on the pathogenesis and biological mechanisms of obesity, the interaction between adipose tissue and the immune system, the role of genetic and environmental factors, the progression of cardiovascular complications, and the associationof obesity and inflammation with type 1 and type 2 diabetes, as well as gestational diabetes. This volume also includes practical recommendations for preventing and managing these conditions using both lifestyle modifications and pharmacological interventions.
Written by experts in the field, Obesity, Diabetes and Inflammation: Molecular Mechanisms and Clinical Management addresses the role of inflammation in both obesity and diabetes, its effect on vascular and non-vascular pathologies, oxidative stress, genetics, and epigenetics. This text aims to be a valuable resource for researchers, clinicians, and students of medicine at all levels.
Table of Content
Inflammation: Pathogenesis and Biological Markers.- Obesity and Inflammation.- Inflammation and Diabetes Mellitus.- Diabetes, Obesity, and Oxidative stress.- Advanced Glycation End-Products and Diabetes.- Genetic and Epigenetic Basis of Obesity-Induced Inflammation and Diabetes.- Inflammation and Vascular Pathologies.- Environmental and Lifestyle Factors Influencing Inflammation and Type 2 Diabetes Onset.- Inflammation in Pregnant Women with Obesity and Gestational Diabetes.- Potential Pharmaceutical and Non-Pharmaceutical Approaches to Obesity and Diabetes: Focus on Inflammation.
About the author
Dimiter Avtanski, Ph.D. is currently a Director of the Endocrine Research Laboratory at Friedman Diabetes Institute of Lenox Hill Hospital in New York City, Associate Professor of Medicine at Donald and Barbara Zucker School of Medicine at Hofstra/Northwell in Hempstead, New York, and Assistant Professor at the Institute of Bioelectronic Medicine at Feinstein Institutes for Medical Research in Manhasset, New York. He received his M.Sc. degree in Biology and Chemistry from Sofia University in Bulgaria and his Ph.D. from the Bulgarian Academy of Sciences in collaboration with Beth Israel Medical Center at Albert Einstein College of Medicine in New York City. Dr. Avtanski specialized at Leipzig University, Germany, and completed seven years of post-doctoral fellowships at The Johns Hopkins University School of Medicine in Baltimore, Maryland. His main research focuses on the connection between obesity, diabetes, and breast cancer progression.Dr. Leonid Poretskyis Chief, Division of Endocrinology; Associate Chairman for Research; Director of the Gerald J. Friedman Diabetes Institute; and the Founding Director, The Gerald J. Friedman Transgender Program for Health and Wellness—all in the Department of Medicine, Lenox Hill Hospital, New York City. He is also Professor of Medicine at Hofstra Northwell School of Medicine and Feinstein Institutes for Medical Research. Dr. Poretsky was born in St. Petersburg, Russia, where he graduated from First (Pavlov) Medical Institute summa cum laude in 1977. Upon immigrating to the United States in 1979 and completing medical residency, he graduated from the endocrinology fellowship at Boston’s Beth Israel Hospital (now Beth Israel/Deaconess Medical Center) and Harvard Medical School. He has authored over 150 publications and is the editor of a 1, 000 page textbook entitled “Principles of Diabetes Mellitus”, currently in its 3rd edition. He is also the editor of “Contemporary Endocrinology” and co-editor of “Transgender Medicine: A Multidisciplinary Approach, ” all published by Springer Publishing, Inc. His research interests include the relationship between energy metabolism and reproduction, endocrinological aspects of HIV-infection, and clinical studies in diabetes. His research projects have been supported over the years by philanthropy, industry and government grants, including the grants from the National Institutes of Health (NIH) and the New York State Department of Health. He has served on the NIH grant review committees and on the editorial boards of the Journal of Clinical Endocrinology and Metabolism and other journals.
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