Jerome Schultz & Milan Mrksich 
Biosensing 
International Research and Development

We have come to know that our ability to survive and grow as a nation to a very large degree depends upon our scientific progress. Moreover, it is not enough simply to keep abreast of the rest of the world in scientific matters. 1 We must maintain our leadership. President Harry Truman spoke those words in 1950, in the aftermath of World War II and in the midst of the Cold War. Indeed, the scientific and engineering leadership of the United States and its allies in the twentieth century played key roles in the successful outcomes of both World War II and the Cold War, sparing the world the twin horrors of fascism and totalitarian communism, and fueling the economic prosperity that followed. Today, as the United States and its allies once again find themselves at war, President Truman’s words ring as true as they did a half-century ago. The goal set out in the Truman Administration of maintaining leadership in science has remained the policy of the U.S. Government to this day: Dr. John Marburger, the Director of the Office of Science and Technology (OSTP) in the Executive Office of the President made remarks to that effect during his confirmation hearings in October 2 2001.

Table of Content

Infrastructure Overview.- Optical Biosensing.- Electro-Based Sensors and Surface Engineering.- Cell and Tissue-Based Sensors.- Mass Spectrometry and Biosensing Research.- Microfabricated Biosensing Devices: MEMS, Microfluidics, and Mass Sensors.- Information Systems for Biosensing.