Lloyd R. Snyder & Joseph J. Kirkland 
Introduction to Modern Liquid Chromatography 

The latest edition of the authoritative reference to HPLC

High-performance liquid chromatography (HPLC) is today the
leading technique for chemical analysis and related applications,
with an ability to separate, analyze, and/or purify virtually any
sample. Snyder and Kirkland’s Introduction to Modern Liquid
Chromatography has long represented the premier reference to
HPLC. This Third Edition, with John Dolan as added coauthor,
addresses important improvements in columns and equipment, as well
as major advances in our understanding of HPLC separation, our
ability to solve problems that were troublesome in the past, and
the application of HPLC for new kinds of samples.

This carefully considered Third Edition maintains the
strengths of the previous edition while significantly modifying its
organization in light of recent research and experience. The text
begins by introducing the reader to HPLC, its use in relation to
other modern separation techniques, and its history, then leads
into such specific topics as:

* The basis of HPLC separation and the general effects of
different experimental conditions

* Equipment and detection

* The column–the ‘heart’ of the HPLC system

* Reversed-phase separation, normal-phase chromatography,
gradient elution, two-dimensional separation, and other
techniques

* Computer simulation, qualitative and quantitative analysis, and
method validation and quality control

* The separation of large molecules, including both biological
and synthetic polymers

* Chiral separations, preparative separations, and sample
preparation

* Systematic development of HPLC separations–new to this
edition

* Troubleshooting tricks, techniques, and case studies for both
equipment and chromatograms

Designed to fulfill the needs of the full range of HPLC users, from
novices to experts, Introduction to Modern Liquid
Chromatography, Third Edition offers the most up-to-date,
comprehensive, and accessible survey of HPLC methods and
applications available.

About the author

Lloyd R. Snyder, Ph D, is a Principal at LC Resources in
Walnut Creek, California. He is the author or coauthor of several
books including An Introduction to Separation Science, Introduction
to Modern Liquid Chromatography, Second Edition, the bestselling
Practical HPLC Method Development, Second Edition, and the
comprehensive High-Performance Gradient Elution, all published by
Wiley.

Joseph J. Kirkland, Ph D, is Vice President of Research
and Development for Advanced Materials Technology, Inc., and
coauthor of Introduction to Modern Liquid Chromatography, Second
Edition, Practical HPLC Method Development, Second Edition, and
Modern Size-Exclusion Liquid Chromatography, Second Edition, all
published by Wiley.

John W. Dolan, Ph D, is a Principal at LC Resources. He is
author of the popular ‘LC Troubleshooting’ column in LCGC magazine
and coauthor with Lloyd Snyder of Troubleshooting LC Systems and
High-Performance Gradient Elution.