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The third of four volumes discusses the role of ubiquitin-mediated protein breakdown in cellular regulation and physiology. Required reading for molecular biologists, cell biologists and physiologists with an interest in the topic.
€219.99
Inhoudsopgave
Ubiquitin: a new player in the peroxisome fieldThe ubiquitin-proteasome system and muscle development
The COP9 signalosome: structural and biochemical conservation and its roles in the regulation of plant development
Ubiquitin and protein sorting to the lysosome
ISG15-Dependent Regulation
The role of the ubiquitin proteasome pathway in the regulation of the cellular hypoxia response
p97 and ubiquitin: A complex story
Cdc48 (p97) and its co-factors
Deubiquitylating enzymes, cell proliferation, and cancer
Over de auteur
John Mayer obtained his MS and Ph D degrees from the University of Birmingham (UK). He is currently serving as Professor of Biochemistry at the School of Biomedical Sciences at Nottingham University.For the past 30 years, he has investigated intracellular proteolysis and particularly the ubiquitin/proteasome system. Presently, he is particularly interested in intracellular proteolysis in relation to neurodegenerative illnesses.
Aaron Ciechanover obtained his MD from the Hebrew University in Jerusalem (Israel), and his Ph D from the Technion-Israel Institute of Technology in Haifa, where he is presently serving as Professor of Biochemistry. Professor Ciechanover is known for his discovery of the first ubiquitin system mutant cell, demonstrating the role of the ubiquitin-proteasome proteolytic system in protein degradation in vivo. In 2004, he has received the Nobel Prize in Chemistry for his ground-breaking work on the ubiquitin-proteasome system.
Martin Rechsteiner is Professor of Biochemistry at the University of Utah in Salt Lake City (USA). He is interested in the proteasome component of the ubiquitin-proteasome pathway. He has identified several key regulators of proteasome function and is currently working on their structural and functional elucidation.
Taal Engels ● Formaat PDF ● Pagina’s 238 ● ISBN 9783527620296 ● Bestandsgrootte 7.0 MB ● Editor R. John Mayer & Aaron J. Ciechanover ● Uitgeverij Wiley-VCH ● Gepubliceerd 2008 ● Editie 1 ● Downloadbare 24 maanden ● Valuta EUR ● ID 2441015 ● Kopieerbeveiliging Adobe DRM
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