Cancer is a very aggressive disease and currently it has been considered a challenge to oncologists and cancer patients worldwide. Nowadays, several therapeutic strategies had improved toward last decades. Surgery is many times still the best curative treatment, mainly in early stage disease. However, Radiotherapy and chemotherapy acquired a main role in this scenario. Target therapies were introduced for medical oncology practice and are demonstrating a hallmark of a new era in cancer treatment. More recently, immunotherapy has been considered the novel cornerstone in cancer treatment. The 2nd edition of the International Manual of Oncology Practice (i MOP) emerged after the great success of the i MOP 1st edition as a reference for medical oncologists and medical residents in the field. In this edition, several chapters were revised and its addresses from the molecular issues of cancer sciences to the clinical practice in medical oncology. In addition, multiple choice questions and clinical cases were included in the main chapters in order to improve the reader learning. The book focuses systemic treatments in many areas of medical oncology, such as breast cancer, gastrointestinal, thoracic, urological oncology, head and neck tumors, bone tumors, sarcomas and palliative care. The topics herein discussed will provide the readers a step forward in the medical oncology practice understanding and give facilities for help in cancer patient treatments.
Table of Content
1
Cancer screening and epidemiology
R.A. De Mello
ramello@ualg.pt or ramondemello@doctors.org.uk
UALG, Portugal
2
Cancer stem cells
José Bragança
jebraganca@ualg.pt
UALG, Portugal
3
Apoptosis
Richard Hill
richard.hill@port.ac.uk
UALG, Portugal
4
Angiogenesis
Patrícia Madureira
pamadureira@ualg.pt
UALG, Portugal
5
Genetic basis of metastasis
Mehmet Gunduz
mehmet.gunduz@gmail.com
Turgut Ozal University, Turkey
6
Anti-cancer Drugs
Wolfgang Link
walink@ualg.pt
UALG, Portugal
7
Immuno-oncology
Pedro Madureira
ramondemello@gmail.com
ICBAS Portugal
8
Health Econimics
Nelson Teichnelsonteich@americasoncologia.com.br
Américas Oncologia, Rio de Janeiro, Brazil
PART II – SOLID TUMORS
THORACIC
9
Non-Small Cell Lung cancer
A. Tantraworasin
ohm_med@hotmail.com
Chiang Mai University, Thailand
10
Small cell lung cancer
A. Tantraworasin
ohm_med@hotmail.com
Chiang Mai University, Thailand
11
Mesothelioma
Vangelis Karamitrousis
v-a-g-@hotmail.com
Alexandroupolis, Greece
12
Thymus
Hakaru Tadokoro
ramondemello@gmail.com
UNIFESP, Brazil
BREAST
13
Breast
Ines Monteiro
ines.pcmonteiro@gmail.com
Lausanne, Switezerland
GASTROINTESTINAL
14
OesophagealKarima Oualla
karimarauf@hotmail.comFes, Marroco
15
Gastric
Luis Castelo-Branco
luismocb@hotmail.com
Faro, Portugal
16
Colon
Nora Forones
noraforones@gmail.com
UNIFESP, Brazil
17
Rectal
JInhui Zhu
ramondemello@gmail.com
China
18
Anal Canal Cancer
Hakaru Tadokororamondemello@gmail.com
UNIFESP, Brazil
19
Small intestine
Pedro Aguiar Jr
pnajpg@hotmail.com
Santo André, Brazil20
Liver Cancer
R. A. DE Mello
ramondemello@gmail.com
UNIFESP, Brazil
21
Pancreatic Cancer
George Antoniou
dr.antoniou@gmail.com
London, UKGYNECOLOGICAL TUMORS
22
Ovarian
Renata Justa
renatajusta@gmail.com
ICC, Brazil
23
Cervical
Alvaro Henrique Ingles Garces
alvarohenriq@yahoo.com.br
INCA, Brazil
24
Vagina
Nikolaou Michail
nikolaoumike@hotmail.com
Larissa, Greece
25
Gestacional trophoblastic disease
Donald Peter Goldstein
DGOLDSTEIN@partners.org
Boston, MA, USA
GENITO-URINARY
26Prostate Cancer
Arlindo Ferreira
ajrsferreira@gmail.com
Lisboa, Portugal
27
Renal Cell Carcinoma
Fernando Nunesfernando.nunes@clion.com.br
Salvador, Brazil
28
Urothelial Cancer
Ramy F. Youssefryaacoub@uci.edu
California, USA
29
Germ-Cell Tumors
Giannis Mountzios
gmountzios@gmail.com
Athens, Greece29.1
Penile Cancer
Nikolaos Tsoukalas
tsoukn@yahoo.gr
London, UK
30Squamous Head and neck
Jean-Pascal Machiels
jean-pascal.machiels@uclouvain.be
Brussels, Belgium
31
Thyroid cancer
Washington Luizwwgois@gmail.com
Fortaleza, Brazil
32
Parotid Gland Tumors
José Aurillo Rocha
jaurillo@hotmail.com
Fortaleza, BrazilSKIN, SOFT TISSUE, BONE, GIST AND ENDOCRINE
33Melanoma
Paolo Asciertopaolo.ascierto@gmail.com
Napoli, Italy
34
Soft Tissue Sarcomas
Carlos Marcio
carlossmarcio@gmail.com
Fortaleza, Brazil
35
Bone Sarcomas
Hakaru Tadokoro
ramondemello@gmail.com
UNIFESP, Brazil
36
GIST
R. A. De Mello
ramondemello@gmail.com
Brazil/Switzerland
37
NET
Yim KL
yimkl2000@hotmail.com
Cardiff, UK
38
Primary brain tumor
Hakaru Tadokoro
ramondemello@gmail.com
UNIFESP, Brazil
PART III – HEMATO-ONCOLOGY
39
Acute Lymphoblastic Leukemia
Eddy Supriyadi
e.supriyadi@gadjahmada.edu
Indonesia
40
Myelodisplastic Syndrome
Ronald Feitosa
ronaldfpinheiro@uol.com.br
Fortaleza, Brazil
PART IV – PALLIATIVE CARE AND SUPPORTIVE CARE
41
Metabolic disturbance/paraneoplasic syndromes
Carmélia Barreto
carmeliabarreto@gmail.com
Sao Paulo, Brazil
42Spinal medular compression
Hakaru Tadokororamondemello@gmail.com
São Paulo, Brazil43
Superior vena cava syndrome
Maria Tolia
mariatolia1@gmail.com
Larissa, Greece
44
Febrile neutropenia
Bora Lim
naborala@gmail.com
Texas, USA
45
Chemotherapy-Induced Nausea and Vomiting
Rudolph M. Navari
rmnavari@gmail.com
Indiana University School of Medicine South Bend, USA
46
Asthenia
F. Koinis
phillipkoinis@gmail.com
Athens, Greece
47
Oncological pain
R.A. De Mello
ramondemello@gmail.com
UALG, Portugal
48
Bone Metastases
Arlindo Rebelo-Ferreira
arjsferreira@gmail.com
Lisbon, Portugal
49
Brain metastasis
Tiago Pádua Costa
tiagopadua1@hotmail.com
São Paulo, Brazil
50
Palliative care
Débora Galdêncio
debora_galgencio@yahoo.com.br
Manaus, Brazil
About the author
Ramon Andrade de Mello, MD, Ph DUniversity of Algarve, Portugal
Ramon Andrade Bezerra de Mello received the MD degree at the Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil, with MD recognition from University of Lisbon, Portugal, and holds the Certificate in Medical Oncology by passing the European examination of ESMO (European Society for Medical Oncology), Lugano, Switzerland. He completed specialization in medicine and molecular oncology and his Ph D in Oncology (lung cancer) at the Faculty of Medicine, University of Porto, Portugal. He also completed a post-doctoral clinical research fellowship in lung cancer clinical trials at the Lung Unit, Royal Marsden NHS Foundation Trust, Chelsea, London, United Kingdom, supported by the ESMO. Currently, he works in the Department of Medical Oncology at the Portuguese Oncology Institute, Porto, Portugal, and he teaches at the Department of Medicine of the University of Porto and School of Medicine, University of Algarve, Faro, Portugal. He is medical director of Oncoclínica/Euroclinics, Porto, Portugal. Prof. de Mello performs both basic and clinical research on angiogenesis, palliative medicine, internal medicine, colorectal cancer and lung cancer; further, he has an active office working. He is editor of 2 books (Tamoxifen Concepts and Cancer: New Paradigms and Vimentin Concepts and Molecular Mechanisms, Nova Science, NY, USA, 2013), author of several scientific articles, chapters and comments on basic and clinical research. He presented more than 50 papers in congresses and conferences in several countries, such as United States, Sweden, Brazil, Portugal and Spain. Furthermore, he serves as editorial board of several reputed scientific journals, such as PLo S ONE, Rare tumors, Oncology Reviews and scientific reviewer of the British Journal of Cancer, Journal of Thoracic Oncology, Annals of Internal Medicine and The Lancet. He participates as expert reviewer of grant applications at the University of Coimbra, Portugal, National Science Centre, Kraków, Poland, and the British Lung Foundation, London, UK. Prof. de Mello is an active member of the ESMO Young Oncologist Committee and consultant at Pfizer gastric cancer advisory board.
SHORT CV GIANNIS MOUNTZIOS MD, MSc, Ph D
Dr Giannis Mountzios was born in Larissa, Greece, in 1974. He obtained his medical degree (MD) from the Aristotle University of Thessaloniki in 1998 with a scholarship from the Greek Ministry of Education and graduated from the Hellenic Military Medical Academy the same year. He completed his residency in Internal Medicine at the Airforce General Hospital of Athens and in Medical Oncology at the University of Athens School of Medicine, “Alexandra” University Hospital (Pr. M.A. Dimopoulos). He then obtained a master (MSc) in translational and clinical research in Oncology from the Institut Gustave-Roussy and the University Paris XI (Paris-Sud), France, in 2007 (Pr. Jean-Charles Soria) and became board-specified in Medical Oncology in 2009. In 2010 he obtained his Ph D in Medical Oncology from the University of Athens School of Medicine. He is currently working as a consultant Medical Oncologist at the University of Athens School of Medicine. Dr Mountzios has received fellowships from the American Society of Clinical Oncology (Young Investigator award), the European Society for Medical Oncology (Annual Fellowship for Translational Research in 2005, Annual Fellowship for Clinical Research in 2009) and the Hellenic Society for Medical Oncology (HESMO). He is currently the General Secretary of the board of directors of HESMO, former chair of the HESMO young medical oncologists committee and former member of the steering committee of the young medical oncologists of ESMO.
SHORT CURRICULUM VITAE
Álvaro Tavares
Álvaro A. Tavares, born in 1964, obtained his degree in Biochemistry from the University of Lisbon, Portugal. He later obtained a M.Sc. in Molecular Biology from the New University of Lisbon, and a Ph D in Biomedical Sciences from the University of Porto, Portugal. He then moved to Scotland where for five years was a Post-doctoral at the Department of Anatomy and Physiology of the University of Dundee. In 1999, having been appointed professor at the Instituto Superior Técnico , Lisbon, he started his own research group at the Gulbenkian Science Institute. In 2009 he moved to the University of Algarve, to the newly formed Department of Biomedical Sciences and Medicine, where he currently directs the Cell Division and Cancer Biology Research Group.
In the course of his research career, Álvaro Tavares has studied proteolytic systems in rat liver mitochondria, proteolysis regulation in differentiation in the plant Lupinus albus, genetic regulation and expression in yeast S. cereviseae, and molecular and genetic characterization of genes required for cell proliferation in Drosophila melanogaster. The underlying theme behind the current work of his laboratory is the basic biology of mitotic cell division, in particular the aspects regulating the formation of a bipolar mitotic spindle and the connection between centrosomes and cytokinesis. The ultimate goal is to understand how modifications of these processes contribute to the transformation of normal into cancer cells. These problems are approached through a combination of biochemical, genetic and cytologic techniques, taking advantage of Drosophila melanogaster genetics and human tissue cultured cells.
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