Stephen M. Roberts & Robert C. James 
Principles of Toxicology 
Environmental and Industrial Applications

A fully updated and expanded edition of the bestselling guide on
toxicology and its practical application

* Covers the diverse chemical hazards encountered in the
modern work and natural environment, and provides a practical
understanding of these hazards

* New chapters cover the emerging areas of toxicology
such as omics, computational toxicology, and nanotoxicology

* Provides clear explanations and practical
understanding of the fundamentals necessary for an understanding of
the effects of chemical hazards on human health and
ecosystems

* Includes case histories and examples from industry
demonstrate the application of toxicological principles

* Supplemented with numerous illustrations to clarify
and summarize key points, annotated bibliographies, and a
comprehensive glossary of toxicological terms

Table of Content

Contributors vii

Preface ix

1 General Principles of Toxicology 1

Robert C. James, Stephen M. Roberts, and Phillip L.
Williams

2 Xenobiotic Absorption, Distribution, Metabolism, and Excretion
29

Michael R. Franklin

3 Toxicokinetics 59

Rebecca A. Clewell and Harvey J. Clewell III

4 Omics Technologies in Toxicology 89

Mary Jane Cunningham

5 Toxicity of the Hematopoietic System 103

Sherilyn A. Gross

6 Hepatotoxicity: Toxic Effects on the Liver 125

Robert C. James and Stephen M. Roberts

7 Nephrotoxicity: Toxic Responses of the Kidney 139

Lawrence H. Lash

8 Neurotoxicity: Toxic Effects on the Nervous System 157

William M. Caudle and Gary W. Miller

9 Dermatotoxicity: Toxic Effects on the Skin 169

Sailesh Konda and Howard I. Maibach

10 Pulmonotoxicity: Toxic Effects in the Lung 179

Cuiqing Liu and Qinghua Sun

11 Immunotoxicity: Toxic Effects on the Immune System 197

Eric S. Sobel and Stephen M. Roberts

12 Toxic Effects on Reproduction 211

Mary L. Hixon

13 Developmental Toxicology 223

Vincent F. Garry and Peter L. Truran

14 Mutagenesis and Genetic Toxicology 235

Martha M. Moore, Meagan B. Myers, and Robert H. Heflich

15 Chemical Carcinogenesis 259

James E. Klaunig

16 Properties and Effects of Metals 283

David B. Mayfield, Ari S. Lewis, Lisa A. Bailey, and Barbara D.
Beck

17 Properties and Effects of Pesticides 309

Janice Britt

18 Properties and Effects of Solvents and Solvent-Like Chemicals
325

Christopher M. Teaf, Michele M. Garber, and J. Michael
Kuperberg

19 Nanotoxicology 359

Hongbo Ma, Steve Diamond, Georgia Hinkley, and Stephen M.
Roberts

20 Computational Toxicology 373

Richard S. Judson, David M. Reif, and Keith A. Houck

21 E pidemiological Issues in Occupational and Environmental
Health 391

Michael S. Bloom and John E. Vena

22 Occupational and Environmental Health 411

Brenda S. Buikema, T. Renée Anthony, and Fredric
Gerr

23 Human Health Risk Assessment 425

Leah D. Stuchal, Robert C. James, and Stephen M. Roberts

Glossary 457

Index 471

About the author

STEPHEN M. ROBERTS , Ph D, is Professor and Program Director of the Center for Environmental and Human Toxicology at the University of Florida, Gainesville, Florida, USA.

ROBERT C. JAMES, Ph D, is Senior Principal Scientist, Tox Strategies in Boise, ID, Tallahassee, Florida, USA.

PHILLIP L. WILLIAMS, Ph D, is Dean of the College of Public Health and Georgia Power Professor of Environmental Health Science at the University of Georgia, Athens, Georgia, USA.