Sean Ekins & Jinghai J. Xu 
Drug Efficacy, Safety, and Biologics Discovery 
Emerging Technologies and Tools

Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.

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Preface.

Acknowledgments.

Contributors.

PART I: DRUG EFFICACY AND SAFETY TECHNOLOGY.

1. Focus on Fundamentals: Towards Better Therapeutic Index
Prediction (Jinghai J. Xu and Li J. Yu).

2. High-Throughput Protein-Based Technologies and Computational
Models for Drug Development, Efficacy and Toxicity (Leonidas G.
Alexopoulos, Julio Saez-Rodriguez and Christopher W. Espelin).

3. Cellular Systems Biology Applied to Pre-Clinical Safety
Testing: A Case Study of Cell Ciphr¯TM
Profiling (Lawrence Vernetti, William Irwin, Kenneth A. Giuliano,
Albert Gough, Kate Johnston and D. Lansing Taylor).

4. Systems Pharmacology, Biomarkers and Biomolecular Networks
(Aram Adourian, Thomas N. Plasterer, Raji Balasubramanian, Ezra
Jennings, Shunguang Wang, Jan van der Greef, Robert Mc Burney,
Pieter Muntendam, and Noubar Afeyan).

5. Zebrafish Models for Human Diseases and Drug Discovery
(Hanbing Zhong, Ning-Ai Liu and Shuo Lin).

6. Toxicity Pathways and Models: Mining for Potential Side
Effects (Sean Ekins and Josef Scheiber).

7. Computational Systems Biology Modeling of Dosimetry and
Cellular Response Pathways (Qiang Zhang, Yu-Mei Tan, Sudin
Bhattacharya and Melvin E. Andersen).

8. Stem Cell Technology for Embryotoxicity, Cardiotoxicity and
Hepatotoxicity Evaluation (Julio C. Davila, Donald B. Stedman,
Sandra J. Engle, Howard I. Pryor II and Joseph P. Vacanti).

9. Telemetry Technology for Preclinical Drug Discovery and
Development (Yi Yang).

PART II. BIOLOGICS TECHNOLOGY.

10. Nanotechnology to Improve Oral Drug Delivery (Mayank D.
Bhavsar, Shardool Jain, and Mansoor M. Amiji).

11. Functional Glycomics and the Future of Glycomic Drugs (Ram
Sasisekharan).

12. Modeling Efficacy and Safety of Engineered Biologics (Jeff
Chabot and Bruce Gomes).

13. Regulation of Gene Expression by Small, Non-Coding RNAs:
Practical Applications (Roman Herrara and Eric Tien).

PART III. FUTURE PERSPECTIVE.

14. Future Perspectives of Biological Engineering in
Pharmaceutical Research: The Paradigm of Modeling, Mining,
Manipulation and Measurements (Jinghai J. Xu, Sean Ekins, Michael
Mc Glashen and Douglas Lauffenburger).

Index.

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Sean Ekins, MSc, PHD, DSc, is the Principal at Collaborations in
Chemistry; and Adjunct Associate Professor in the Department of
Pharmaceutical Sciences at the University of Maryland, School of
Pharmacy. Dr. Ekins has published widely on ADME/Tox, systems
biology, computational, and in vitro drug discovery approaches. He
has previously edited two Wiley books: Computer Applications in
Pharmaceutical Research and Development (2006) and Computational
Toxicology: Risk Assessment for Pharmaceutical and Environmental
Chemicals (2007).

Jinghai J. Xu, PHD, is Director of Automated Biotechnology at
Merck. Previously he headed predictive toxicology at Pfizer, where
he led research activities in drug-induced liver injury, genetic
toxicology, drug transporters, assay development, high content
screening, in vitro in vivo correlations, systems biology, and
systems toxicology. Dr. Xu has served on steering committees of
academic-industry and industry-industry collaborations, and as a
guest lecturer at the Massachusetts Institute of Technology.