Slobodan Sasic 
Pharmaceutical Applications of Raman Spectroscopy 

Raman spectroscopy has advanced in recent years with increasing use
both in industry and academia. This is due largely to steady
improvements in instrumentation, decreasing cost, and the
availability of chemometrics to assist in the analysis of data.

Pharmaceutical applications of Raman spectroscopy have developed
similarly and this book will focus on those applications. Carefully
organized with an emphasis on industry issues, Pharmaceutical
Applications of Raman Spectroscopy, provides the basic theory of
Raman effect and instrumentation, and then addresses a wide range
of pharmaceutical applications. Current applications that are
routinely used as well as those with promising potential are
covered. Applications cover a broad range from discovery to
manufacturing in the pharmaceutical industry and include
identifying polymorphs, monitoring real-time processes, imaging
solid dosage formulations, imaging active pharmaceutical
ingredients in cells, and diagnostics.

สารบัญ

Preface.

Contributors.

1. Introduction to Raman Spectroscopy (Yukihiro Ozaki
and Slobodan Sasic).

1.1 Histor of Raman Spectrodcopy.

1.2. The Principle of Raman Spectroscopy.

1.3 An Example of Simpel Raman Spectrum: Raman Spectrum of
Water.

1.4 Characteristics of Raman Spectroscopy.

1.5 The Classic Theory fo Raman Effect.

1.6 The Quantum Theory of Raman Scattering.

1.7 Ctross Section.

1.8 Relevance to Pharmaceuticals.

1.9 Resonance Raman Effect.

1.10 Instrumentation for Raman Spectroscopy.

2. Quantitative Analysis of Solid Dosage Formulations by
Raman Spectroscopy (Steven E.J.Bell).

2.1 Introduction.

2.2 Quantitative Analysis.

2.3 Instrumental Parameters.

2.4 Experimental Considerations.

2.5 Nonstandard Samples.

2.6 Conclusions.

3. Surface Enhanced Resonance Raman Scatttering (W.
Ewen Smith).

3.1 Theory.

3.2 The Exper4imental Setup.

3.3 Examples of SERS/SERRS Assays.

4. Raman Spectroscopy for Identifying Polymorphs (Fred
Laplant and Anne De Paepe).

4.1 Introduction of Polymorphism.

4.2 Instrumental Methods of Polymorph Characterization.

4.3 Polymorph Screening.

4.4 Process Control.

4.5 Polymorph Quantitation.

4.6 Calibration Set and Sample Preparation.

4.7 Quantitation.

4.8 Intellectual Property.

5. Raman Spectroscopy for Monitoring Real-time Processes in
the Pharmaceutical Industry (Kevin L. Davis, Mark S. Kemper
and Ian R. Lewis).

5.1 Introduction.

5.2 A Brief History of Raman Spectroscopy.

5.3 Basic Theory of Raman Spectroscopy.

5.4 General Instrumentation for Raman Spectroscopy.

5.5 The Choice-Dispersive or FT?.

5.6 Process Analysis and PAT.

5.7 Why Choose Raman as a PAT Tool? The Need for Raman.

5.8 Data Analysis.

5.9 Applications.

5.10 Conclusions.

6. Raman Chemical Imaging of Solid Dosage Formulations
(Slobodan Sasic).

6.1 Methods for Chemcial Imaging.

6.2 Data Analysis.

6.3 Experimental.

6.4 Applications.

7. In vivo Raman Confocal Microspectroscopy of Skin
(Andre van der Pol, William M. Riggs and Peter J.
Caspers).

7.1 Introduction.

7.2 Applications.

7.3 Summary and Discussion.

8. Raman Microspectrscopy and Imgaging of Active
Pharmaceutical Ingredients in Cells (Jian Ling).

8.1 Introduction.

8.2 Current Appraoches to Drug Imaging.

8.3 Raman Spectroscopy and Raman Imaging.

8.4 Raman Microspectroscopy and Imaging for Drug Research.

8.5 Raman Intensity, Fluorescence Background, and SNR.

8.6 Techniques to Improve SNR in Raman Imaging.

8.7 Enhanced Raman Images with Postprocessing.

8.8 Raman Imaging of Intracellular Distribution of Paclitaxel in
Living Cells.

8.9 Raman Imaging of Intracellular Distribution of Sulindac
Sulfide in Fixed Cells.

8.10 Conclusions and Future Outlook.

Index.

เกี่ยวกับผู้แต่ง

Principal Scientist, Analytical Research & Development, Pfizer, Inc., Sandwich, UK