Viacheslav A. Petrov 
Fluorinated Heterocyclic Compounds 
Synthesis, Chemistry, and Applications

A thorough survey of synthetic methods, chemistry, and
applications of major classes of fluorinated heterocycles

Merging organic, heterocyclic, and fluoroorganic chemistry,
fluorinated heterocyclic compounds have distinctively desirable
properties suitable for use in pharmaceuticals and agrichemicals,
especially their ability to penetrate the cell membrane barrier for
drug absorption. Offering a needed overview of this relatively new
addition to the heterocyclic family, this essential reference
provides the latest state-of-the-art information on key application
areas within fluorine chemistry.

With contributions from experts from both industry and academia,
the book covers the chemistry, synthesis, and applications of
fluorinated heterocycles with chapters on:

* Three-, four-, five-, six-, and seven-membered
fluorine-containing heterocycles

* Fluorinated nucleosides

* Fluorointermediates

* Applications of fluorinated heterocycles in agricultural
products

* Pharmaceuticals containing fluorinated heterocycles

* Technical applications of fluorinated heterocycles

Written by a team of world-recognized experts in the area of
organic and industrial chemistry of fluorine, Fluorinated
Heterocyclic Compounds: Synthesis, Chemistry, and Applications
will prove valuable to both students and researchers from academia
and industry seeking further knowledge of the synthetic methods,
chemistry, and applications of major classes of fluorinated
heterocycles.

Table of Content

PREFACE.

CONTRIBUTORS.

INTRODUCTION: NOMENCLATURE OF POLYFLUORINATED
HETEROCYCLES.

PART I SYNTHESIS AND CHEMISTRY OF FLUORINATED
HETEROCYCLES.

1 Fluorinated Three-Membered Ring Heterocycles (David
M. Lemal and Sudharsanam Ramanathan).

2 Fluorinated Four-Membered Heterocycles (Roman B. Larichev
and Viacheslav A. Petrov).

3 Fluorinated Five-Membered Nitrogen-Containing Heterocycles
(Kenneth L. Kirk).

4 Fluorinated Five-Membered Heterocycles Containing Oxygen,
Sulfur, Selenium, and Phosphorus (Yuriy Shermolovich).

5 Synthesis of Fluorinated Sugars from Fluorine-Containing
Synthons (Xiao-Long Qiu and Feng-Ling Qing).

6 Synthesis of Ring-Fluorinated Pyridines (Anatoliy M.
Shestopalov, Alexander A. Shestopalov, Lyudmila A. Rodinovskaya,
and Anna V. Gromova).

7 Synthesis and Chemical Transformation of Six-Membered Aromatic
Heterocycles Containing Perfluoroalkyl Groups (Viacheslav A.
Petrov).

8 Perfluorinated Six-Membered Aromatic Heterocycles Containing
One or More Heteroatom (Graham Sandford).

9 Perfluorinated Nonaromatic Heterocycles (Viacheslav A.
Petrov).

10 Seven-Membered and Larger Ring-Fluorinated Heterocycles
(Viacheslav A. Petrov).

PART II APPLICATION OF FLUORINATED HETEROCYCLIC
MATERIALS.

11 Agricultural Products Based on Fluorinated Heterocyclic
Compounds (Wonpyo Hong).

12 Pharmaceuticals Containing Fluorinated Heterocyclic Compounds
(Kenji Uneyama and Kenji Sasaki).

13 Practical Uses of Fluorinated Heterocycles (Paul R.
Resnick).

Index.

About the author

Viacheslav A. Petrov is a Research Fellow with Du Pont Central Research and Development in Wilmington, Delaware.