Ebook > Sciences > Chemistry > Vladimir Pliska & Bernard Testa: Lipophilicity in Drug Action and Toxicology (PDF)

Vladimir Pliska & Bernard Testa
Lipophilicity in Drug Action and Toxicology

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Cover of Vladimir Pliska & Bernard Testa: Lipophilicity in Drug Action and Toxicology (PDF)

Lipohilie ist der Schlüssel zum Verständnis der Wirksamkeit von Medikamenten. Trotz ihrer Bedeutung wird diese entscheidende Eigenschaft aber vielfach noch nicht genügend gewürdigt oder verstanden. In diesem Buch präsentieren anerkannte Experten neue theoretische und experimentelle Ergebnisse, die die Bedeutung der Lipophilie belegen und ihr Verständnis ermöglichen. Insbesondere wird die Verbindung zwischen theoretischen Modellen – die Vorhersagen für neue Substanzen ermöglichen – und praxisrelevanten experimentellen Ergebnissen beschrieben.
Nicht zuletzt auch durch seine umfassenden Literaturverweise und die instruktiven Farbtafeln wird dieses Werk für alle in der Wirkstofforschung aktiven Wissenschaftler zu einem unentbehrlichen Hilfmittel werden.

€103.99

Table of Content

From the contents:
Lipophilicity: The empirical tool and the fundamental objective/ Lipophilicity: A history/ Thermodynamics of van der Waals and hydrophobic interactions/ Intramolecular interactions encoded in lipophilicity: their nature and significance/ Lipophilicity measurement by reversed-phase high performance liquid chromatography (RP-HPLC)/ Centrifugal partition chromatography for lipophilicity measurements/ Assessment of distribution – p H profiles/ Estimation of lipophilicty by reversed-phase thin layer chromatography/ The future of log P calculation/ Theoretical calculation of partition coefficients/ Cellular automata model of partitioning between liquid phases

Language English ● Format PDF ● Pages 438 ● ISBN 9783527614981 ● File size 31.6 MB ● Editor Vladimir Pliska & Bernard Testa ● Publisher Wiley-VCH ● Published 2008 ● Edition 1 ● Downloadable 24 months ● Currency EUR ● ID 2455296 ● Copy protection Adobe DRM

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Vladimir Pliska Bernard Testa Han Van De Waterbeemd Raimund Mannhold Hugo Kubinyi Hendrik Timmerman

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