Michael D. Greenberg 
Radical and Radical Ion Reactivity in Nucleic Acid Chemistry 

Comprehensive coverage of radical reactive intermediates in nucleic
acid chemistry and biochemistry

The Wiley Series on Reactive Intermediates in Chemistry and
Biology investigates reactive intermediates from the broadest
possible range of disciplines. The contributions in each volume
offer readers fresh insights into the latest findings, emerging
applications, and ongoing research in the field from a diverse
perspective.

The chemistry and biochemistry of reactive intermediates is
central to organic chemistry and biochemistry, and underlies a
significant portion of modern synthetic chemistry. Radical and
Radical Ion Reactivity in Nucleic Acid Chemistry provides the
only comprehensive review of the chemistry and biochemistry of
nucleic acid radical intermediates.

With contributions by world leaders in the field, the text
covers a broad range of topics, including:

* A discussion of the relevant theory

* Ionization of DNA

* Nucleic acid sugar radicals

* Halopyrimidines

* Oxidative, reductive, and low energy electron transfer

* Electron affinity sensitizers

* Photochemical generative of reactive oxygen species

* Reactive nitrogen species

* Enediyne rearrangements

* Phenoxyl radicals

A unique compilation on the cutting edge of our understanding,
Radical and Radical Ion Reactivity in Nucleic Acid Chemistry
provides an unparalleled resource to student and professional
researchers in such fields as organic chemistry, biochemistry,
molecular biology, and physical chemistry, as well as the
industries associated with these disciplines.

Inhaltsverzeichnis

Preface to Series vii

Introduction ix

Contributors xi

1. Theoretical Modeling of Radiation-Induced DNA Damage 1

Anil Kumar and Michael D. Sevilla

2. Radical Reaction Pathways Initiated by Direct Energy
Deposition in DNA by Ionizing Radiation 41

William A. Bernhard

3. Chemical Reactions of the Radical Cations of Nucleobases in
Isolated and Cellular DNA. Formation of Single-Base Lesions
69

Jean Cadet, Thierry Douki, Didier Gasparutto, Jean-Luc Ravanat,
and J. Richard Wagner

4. Reactivity of Nucleic Acid Sugar Radicals 99

Chryssostomos Chatgilialoglu

5. Pyrimidine Nucleobase Radical Reactivity 135

Marc M. Greenberg

6. Reactivity of 5-Halopyrimidines in Nucleic Acids 163

Ryu Tashiro and Hiroshi Sugiyama

7. Kinetics of Long-Range Oxidative Electron Transfer Through
DNA 191

Kiyohiko Kawai and Tetsuro Majima

8. Radical Intermediates During Reductive Electron Transfer
Through DNA 211

Reji Varghese and Hans-Achim Wagenknecht

9. Low-Energy Electron Interaction with DNA: Bond Dissociation
and Formation of Transient Anions, Radicals, and Radical Anions
239

Leon Sanche

10. Electronic-Affinic Radiosensitizers 295

Peter Wardman

11. Reactions of Reactive Nitrogen Species and Carbonate Radical
Anions with DNA 325

Vladimir Shafirovich, Conor Crean, and Nicholas E.
Geacintov

12. Principles and Applications of Electrochemical Oxidation of
Nucleic Acids 357

H. Holden Thorp and Julie M. Sullivan

13. DNA Damage Due to Diradical-Generating Cyclizations
389

Sean M. Kerwin

14. DNA Damage by Phenoxyl Radicals 421

Richard A. Manderville

Index 445

Über den Autor

Marc M. Greenberg is a Professor of Chemistry and Director
of the Chemistry Biology Interface Graduate Training Program at
Johns Hopkins University. His research uses chemistry,
biochemistry, and biology to fundamentally understand how DNA is
oxidatively damaged, and what the effects of that damage are.

Steven E. Rokita, Ph D, is Professor in the Department of
Chemistry and Biochemistry at the University of Maryland. His
research interests lie in sequence and conformation specific
reactions of nucleic acids, enzyme-mediated activation of
substrates and coenzymes, halogenation and dehalogenation reactions
in biology, aromatic substitution and quinone methide generation in
bioorganic chemistry, and copper- and nickel-mediated reactions in
bioinorganic chemistry.