Rashid Ali & Shahid Ul Islam 
Chemistry and Biological Activities of Ivermectin 

CHEMISTRY AND BIOLOGICAL ACTIVITIES OF IVERMECTIN

The book focuses on the biological activities of ivermectin as well as the significant global utility of IVM since it was first used about 35 years ago.

Ivermectin (IVM) is a ‚wonder drug‘ containing a 16-membered macrocyclic lactone ring system in its structure and derived from the family of avermectins. It was isolated by the fermentation of the soil microorganism Streptomyces avermitilis by Satoshi Omura in 1960 and studied by William C. Campbell in 1981, which allowed for its treatment of onchocerciasis (River Blindness) in Africa. Both scientists subsequently received the 2015 Nobel Prize in Physiology or Medicine. It was approved by the FDA in 1997 for the treatment of Strongyloidiasis and crusted scabies in AIDS patients. After that, IVM has attracted the tremendous attention of the scientific community and has been used for diverse purposes, including as an inhibitor of the causative virus (SARS-Co V-2).

The chief purpose of this volume is to focus on the chemistry and biological activities of ivermectin. The chapters have been arranged in a systematic manner, starting from the historical background and synthesis of IVM to the pharmacological and environmental aspects, followed by diverse applications. Although the usage of ivermectin for the treatment of COVID-19 remains under investigation and controversial, one of the chapters is dedicated to its use. The anti-parasitic, anti-malarial, anti-cancer, and anti-inflammatory activities of IVM are discussed in detail. The anthelminthic and insecticidal roles of IVM are briefly described and there are several cases of IVM in dermatology.

Audience

Researchers, scientists, and postgraduate students working in the fields of organic synthesis, medicinal chemistry, medical science, pharmacy, biotechnology and biomedical sciences.

Über den Autor

Rashid Ali, Ph D, is an assistant professor in the Department of Chemistry, Jamia Millia Islamia, New Delhi, India after receiving his Ph D from the Indian Institute of Technology Bombay in organic and supramolecular chemistry. He has more than 50 research articles in international journals as well as multiple book chapters.

Shahid-ul-Islam, Ph D, is a Research Scientist at the Department of Textile & Fiber Engineering, Indian Institute of Technology Delhi (IIT). His areas of interest are antimicrobial coatings, green chemistry, fibers & polymers, polymeric composites and nanocomoposites, and nano-biotechnology. He has published numerous peer-reviewed research articles in journals of high repute as well as contributions to several books published by the Wiley-Scrivener imprint.