János Fischer & Christian Klein 
Successful Drug Discovery 
Volume 4

Provides unique insider insight into the current drug development process, and what it takes to achieve success

In this fourth volume in the series, inventors and primary developers of drugs that made it to the market continue telling the story of the drugs? discovery and development, and discuss the sometimes twisted route from the first drug candidate molecule to the final marketed one. Beginning with a general section addressing overarching topics for drug discovery, the book offers seven chapters that feature selected case studies describing recently introduced drugs or drug classes. These include small molecule drugs as well as biopharmaceuticals and range across different therapeutic fields. Together, they provide a representative cross-section of the present-day drug development effort.

Successful Drug Discovery: Volume 4 covers trends in peptide-based drug discovery and the physicochemical properties of recently approved oral drugs. The section on drug class studies looks at antibody-drug conjugates and the discovery, evolution, and therapeutic potential of dopamine partial agonists. Featured case studies examine the discovery of Etelcalcetide for the treatment of secondary hyper-parathyroidism in patients with chronic kidney disease; the development of Lenvatinib Mesylate; the discovery and development of Venetoclax; and more.

-Focuses on recently introduced drugs that have not been featured in any textbooks or general references, including Ocrelizumab, a new generation of anti-CD-20 m Ab for the treatment of multiple sclerosis, and Venetoclax, a selective antagonist of BCL-2
-Features personal experiences of successful drug developers from industry and academia
-Endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC)

Successful Drug Discovery: Volume 4 provides a fascinating and informative look into the process of drug discovery and would be a great reference for those in the pharmaceutical industry, organic and pharmaceutical chemists, and lecturers in pharmacy.

Table des matières

PART 1: General Aspects
Trends in Peptide-based Drug Discovery
Physicochemical Parameters of Recently Approved Oral Drugs

PART 2: Drug Class Studies
Antibody-Drug Conjugates: Empowering Antibodies for the Fight against Cancer
Dopamine Partial Agonists – Discovery, Evolution and Therapeutic Potential

PART 3: Case Studies
Discovery of Etelcalcetide for the Treatment of Secondary Hyperparathyroidism in Patients with Chronic Kidney Disease
Development of Lenvatinib Mesylate, an Angiogenesis Inhibitor Targeting VEGF and FGF Receptors
Ocrelizumab : A New Generation of anti-CD-20 m Ab for the Treatment of Multiple Sclerosis
The Story of Rucaparib/Rubraca
Discovery and Development of Venetoclax, a Selective Antagonist of Bcl-2

A propos de l’auteur

Janos Fischer, Ph D, is a Senior Research Scientist at Richter Plc., Budapest, Hungary, and is Chair of the Subcommittee on Drug Discovery and Development of IUPAC.

Christian Klein, Ph D, is Head of Oncology Programs at the Roche Innovation Center Zurich, specialized in the discovery, validation and preclinical development of antibody based cancer immunotherapies and bispecific antibodies.

Wayne Childers, Ph D, is Associate Professor of Pharmaceutical Sciences at Temple University, Philadelphia, USA.