Brian K. Hall & Benedikt Hallgrimsson 
Epigenetics 
Linking Genotype and Phenotype in Development and Evolution

Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in development, disease, and evolution. Chapters cover such topics as morphogenesis and organ formation, conceptual foundations, and cell differentiation, and together demonstrate that the integration of epigenetics into mainstream developmental biology is essential for answering fundamental questions about how phenotypic traits are produced.

Daftar Isi

Epigenetics:

Linking Genotype and Phenotype in Development and Evolution


1. Introduction: Emergent Properties and the Phenotype

Hallgrímsson and Hall


Historical and Philosophical Foundations

2. Historical Foundations

Brian K. Hall


3. Heuristic Reductionism and the Relative Significance of Inheritance

James Grisemer



Approaches to Epigenetics

4. Genomic imprinting

Vett Lloyd



5. Methylation Mapping in Humans

Christoph Grunau, Montpellier


6. Asexuality and Epigenetic Variation

Root Gorelick, Manfred Laubichler and Rachel Massicotte



7. Preformation and the Humpty Dumpty Problem

Ellie Larsen


8. A Principle of Developmental Inertia

Allesandro Minelli



Epigenetics of Vertebrate Organ Development

9. Nervous System Development

Carol Schuurmans


10. Morphogenesis of pigment patterns

Lennart Olsson


11. Interactions of the Cardiac Neural Crest

Margaret Kirby


12. Bone and Cartilage Development

Tamara Franz-Odendaal



13. Muscle-Bone Interactions and the Development of Skeletal Phenotype

Sue Herring


14. Apical Ectoderm in the Developing Vertebrate Limb

Cooper, L.N, Armfield, B.A., J.G.M. Thewissen


15. Role of Skeletal Muscle in the Shaping of Organs, Tissues and Cell Fate Choices

Boris Kablar



Epigenetics in Evolution and Disease

16. Integration, Complexity and Evolvability of the Head

Dan Lieberman


17. Epigenetic interactions: The developmental route to functional integration

Miriam Leah Zelditcha and Donald L. Swiderski


18. Epigenetic Contributions to Adaptive Radiation

Susan Foster


19. Learning, Developmental Plasticity, and the Rate of Morphological Evolution

Rich Palmer and Chris Neufeld


20. Epigenetics: Adaptation or Contingency

Thomas Hansen


21. Dysmorphology

Joan Richtsmeier


22. Human Disease

Peter Gluckman


23. Epigenetics: The Context of Development

Hallgrimsson and Hall

Tentang Penulis

Benedikt Hallgrimsson, Professor in the Department of Cell Biology and Anatomy at the University of Calgary, is coeditor of Variation: A Central Concept in Biology and of Advanced Imaging in Biology and Medicine: Technology, Software Environments, Applications. Brian K. Hall is University Research Professor Emeritus at Dalhousie University. His latest book is Evolution: Principles and Processes.