Gene Expression and its Discontents examines a class of probability models describing how epigenetic context affects gene expression and organismal development, using the asymptotic limit theorems of information theory in a highly formal manner. Taking classic results on spontaneous symmetry breaking abducted from statistical physics in groupoid, rather than group, circumstances, the work suggests that epigenetic information sources act as analogs to a tunable catalyst, directing development into different characteristic pathways according to the structure of external signals. The results have significant implications for epigenetic epidemiology, in particular for understanding how environmental stressors, in a large sense, can induce a broad spectrum of developmental disorders in humans. The authors then apply the perspective to a number of chronic diseases broadly associated with obesity, using data at different scales of observation.
Rodrick Wallace & Deborah Wallace
Gene Expression and Its Discontents
The Social Production of Chronic Disease
Gene Expression and Its Discontents
The Social Production of Chronic Disease
Bahasa Inggeris ● Format PDF ● Halaman-halaman 227 ● ISBN 9781441914828 ● Saiz fail 19.1 MB ● Penerbit Springer New York ● Bandar raya NY ● Negara US ● Diterbitkan 2009 ● Muat turun 24 bulan ● Mata wang EUR ● ID 2149983 ● Salin perlindungan Social DRM