H. G. Wells 
Island of Doctor Moreau 

The Island of Doctor Moreau is a classic of early science fiction and remains one of Wells’ best-known books. The novel is the earliest depiction of the science fiction motif "uplift" in which a more advanced race intervenes in the evolution of an animal species to bring the latter to a higher level of intelligence. It has been adapted to film and other media on many occasions, with Charles Laughton (1933), Burt Lancaster (1977), and Marlon Brando (1996) as the mad doctor.