Montserrat Diéguez & Jan-E. Bäckvall 
Artificial Metalloenzymes and MetalloDNAzymes in Catalysis 
From Design to Applications

An important reference for researchers in the fi eld of metal-enzyme hybrid catalysis
Artifi cial Metalloenzymes and Metallo DNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors — noted experts in the field ? present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner.
The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future:

* Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application
* Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years
* Includes contributions from leading researchers in the field
* Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts

Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and Metallo DNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.

Содержание

1 BASICS
1.1 Preparation of metalloenzymes (repurposing natural metalloenzymes, direct salt complexation, covalent and non-covalent/supramolecular anchoring)
1.2 Preparation of metallo DNAzymes (supramolecular and covalent anchoring)
1.3 Experimental characterization techniques of hybrid catalysts
1.4 Computational studies of metalloenzymes and metallo DNAzymes (from methods and models to design and optimization)
1.5 Directed evolution techniques for the optimization of metalloenzymes and metallo DNAzymes
2 APPLICATIONS
2.1 Hybrid catalysts for the hydrogenation and transfer hydrogenation reactions
2.2 Hybrid catalysts for oxidation reactions
2.3 Hybrid catalysts as Lewis acids
2.4 Hybrid catalysts for C-H activation and other X-H insertion reactions
2.5 Hybrid catalysts for allylic substitution reactions, olefin metathesis, hydroformylation, fluorination, hydrolysis, ….
2.6 Hybrid catalysts in cascade and multi-component processes
2.7 Hybrid catalysts for alternative energy harvest
2.8 Synthesis and application of hybrid catalysts with metalloenzyme-like properties
3 FUTURE PERSPECTIVES

Об авторе

Montserrat Diéguez is Professor of Inorganic Chemistry at the University Rovira i Virgili in Tarragona. She focuses on the sustainable design, synthesis and screening of highly active and selective chiral catalysts for reactions.

Jan-Erling Bäckvall is Professor of Organic Chemistry at the Stockholm University, Sweden. His research includes transition metal-catalyzed organic transformations, biomimetic oxidations, and enzyme catalysis.

Oscar Pàmies is Associate Professor at the Rovira i Virgili University. His research includes asymmetric catalysis, organometallic chemistry, enzyme catalysis and combinatorial synthesis.