John R Thornback & Chris J Jones 
Medicinal Applications of Coordination Chemistry 

Metals in pharmaceuticals have played an increasingly important role in medicine over the last century, particularly in cancer therapy and diagnostic imaging methods. Medicinal Applications of Coordination Chemistry focuses on the role that transition metals play in clinical applications. Medicinal Applications of Coordination Chemistry begins with a brief historical review and an introduction to the chemistry of d- and f- block metals. Subsequent sections discuss metallodrugs for a number of different applications, the design of new drugs and the relationship between structure and function. Key sections include diagnostic applications of metal compounds in anatomical and functional imaging, and therapeutic applications of metals compounds. This book is ideal for researchers in academia and industry and comes complete with examples of real life applications.

สารบัญ

Preface; Chapter 1: INTRODUCTION; 1.1: METALS IN MEDICINE – A HISTORICAL PERSPECTIVE; 1.2: METALS AND HUMAN BIOCHEMISTRY; 1.3: METALLOPHARMACEUTICALS; 1.4: THE SPECIAL PROPERTIES OF METALS; Chapter 2: THE CHEMISTRY OF METALS IN A NUTSHELL; 2.1: THE STRUCTURE OF MATERIALS; 2.2: THE STRUCTURES AND PROPERTIES OF ATOMS; 2.3: THE FORMATION OF COMPOUNDS; 2.4: THE CHEMISTRY OF METALS – AN OVERVIEW; 2.5: BONDING IN METAL COMPLEXES; 2.6: THE MAGNETISM AND SPECTROSCOPY OF METAL COMPLEXES; 2.7: THE ENERGETICS OF METAL COMPLEX FORMATION; 2.8: REACTIONS AT METAL CENTRES; 2.9: REDOX POTENTIALS; 2.10: CONCLUSIONS; Chapter 3: DIAGNOSTIC MEDICINE; 3.1: INTRODUCTION; 3.2: ANATOMICAL IMAGING; 3.3: FUNCTIONAL IMAGING; 3.4: In vitro APPLICATIONS; Chapter 4: THERAPEUTIC MEDICINE; 4.1: THE USE OF METAL COMPOUNDS IN THERAPY; 4.2: CHELATION THERAPY; 4.3: CANCER THERAPY; 4.4: RHEUMATOID ARTHRITIS; 4.5: DIABETES; 4.6: CARDIOVASCULAR SYSTEM; 4.7: THERAPEUTIC RADIOPHARMACEUTICALS; Chapter 5: METALLOPHARMACEUTICAL DESIGN; 5.1: INTRODUCTION; 5.2: STRUCTURE ACTIVITY RELATIONSHIPS; 5.3: FUTURE DIRECTIONS

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Honorary Visiting Professor in Radiochemistry, University of Manchester