Gianpiero D. Palermo & E. Scott Sills 
Intracytoplasmic Sperm Injection 
Indications, Techniques and Applications

This unique, comprehensive text on the male factor infertility experience centers on the current background, applications and techniques for intracytoplasmic sperm injection (ICSI), one of the more commonly utilized procedures in modern assisted reproduction for male infertility, offering insights into the rationale and indications for ICSI and providing an up-to-date discussion on male factor diagnostic tests and microsurgical techniques for ICSI itself. Topics covered include the role of reproductive genetics, the effects of paternal age, the assessment, development and selection of functional human spermatozoa (e.g., Comet assay), both naturally and in the laboratory, and the procedures by which these sperm are injected directly into an oocyte. Comparisons are made between efficacy rates of ICSI versus conventional IVF strategies, and clinical approaches to fertilization failures following ICSI are presented, and intracytoplasmic morphologically selected sperm injection (IMSI) is discussed in detail in a chapter of its own.

Bringing together the latest evidence and written by international leaders in the field, Intracytoplasmic Sperm Injection: Indications, Techniques and Applications is a unique and accessible resource for reproductive endocrinologists, andrologists, geneticists and infertility practitioners and researchers alike.

Table of Content

Male-Factor Infertility: Factoring in the Male Experience.- Intracytoplasmic Sperm Injection: History, Indications, Technique and Safety.- The Role of Reproductive Genetics in Modern Andrology.- Effect of Paternal Age on Reproductive Outcomes: Data from Intracytoplasmic Sperm Injection and Oocyte Donation.- New Paradigms in de Novo Creation of Functional Human Spermatozoa: A Review of Biological Progress towards Clinical Application.- Assessment of Sperm DNA Integrity and Implications for Intracytoplasmic Sperm Injection Outcomes.- Sperm Evaluation Using the Comet Assay.- Automated Morphology Detection from Human Sperm Images.- Clinical Approaches to Male Factor Infertility.- Intracytoplasmic Morphologically Selected Sperm Injection (IMSI): An Overview.- The Human Y-Chromosome: Evolutionary Directions and Implications for the Future of “Maleness”.- Implications of Sperm Source on ICSI Outcome: Assessment of TESE and Other Surgical Sperm Retrieval Methods.- Intracytoplasmic Sperm Injection (ICSI): Applications and Insights.

About the author

Gianpiero D. Palermo, MD, Ph D, Director of Assisted Fertility and Andrology, Blavatnik Distinguished Professor of Reproductive Medicine, Professor of Embryology in Obstetrics and Gynecology, Center for Reproductive Medicine, Weill Cornell Medical College, New York, NY, USA




E. Scott Sills, MD, Ph D, Medical Director, Center for Advanced Genetics, Reproductive Research Section, San Clemente, CA, USA