John Talbot & Jeffrey K. Aronson 
Stephens’ Detection and Evaluation of Adverse Drug Reactions 
Principles and Practice

The detection and evaluation of adverse drug reactions is crucial
for understanding the safety of medicines and for preventing harm
in patients. Not only is it necessary to detect new adverse drug
reactions, but the principles and practice of pharmacovigilance
apply to the surveillance of a wide range of medicinal products.

Stephens’ Detection and Evaluation of Adverse Drug
Reactions provides a comprehensive review of all aspects of
adverse drug reactions throughout the life cycle of a medicine,
from toxicology and clinical trials through to pharmacovigilance,
risk management, and legal and regulatory requirements. It also
covers the safety of biotherapeutics and vaccines and includes new
chapters on pharmacogenetics, proactive risk management, societal
considerations, and the safety of drugs used in oncology and herbal
medicines.

This sixth edition of the classic text on drug safety is an
authoritative reference text for all those who work in
pharmacovigilance or have an interest in adverse drug reactions,
whether in regulatory authorities, pharmaceutical companies, or
academia.

Praise for previous editions

‘This book presents a comprehensive and wide-ranging overview of
the science of pharmacovigilance. For those entering or already
experienced in the pharmaceutical sciences, this is an essential
work.’ – from a review in E-STREAMS

‘…a key text in the area of pharmacovigilance…extensively
referenced and well-written…a valuable resource…’ – from a
review in The Pharmaceutical Journal

About the author

John Talbot, Senior Lecturer, University of Hertfordshire, UK.
Formerly Director, Global Drug Safety, Astra Zeneca R&D
Charnwood, Loughborough, Leicestershire, UK

Jeffrey Aronson, Reader in Clinical Pharmacology, University of
Oxford, Oxford, UK and President Emeritus of the British
Pharmacological Society