Leena Peltonen 
Characterization of Pharmaceutical Nano- and Microsystems 

Learn about the analytical tools used to characterize particulate drug delivery systems with this comprehensive overview

Edited by a leading expert in the field, Characterization of Pharmaceutical Nano- and Microsystems provides a complete description of the analytical techniques used to characterize particulate drug systems on the micro- and nanoscale.

The book offers readers a full understanding of the basic physicochemical characteristics, material properties and differences between micro- and nanosystems. It explains how and why greater experience and more reliable measurement techniques are required as particle size shrinks, and the measured phenomena grow weaker.

Characterization of Pharmaceutical Nano- and Microsystems deals with a wide variety of topics relevant to chemical and solid-state analysis of drug delivery systems, including drug release, permeation, cell interaction, and safety. It is a complete resource for those interested in the development and manufacture of new medicines, the drug development process, and the translation of those drugs into life-enriching and lifesaving medicines.

Characterization of Pharmaceutical Nano- and Microsystems covers all of the following topics:

* An introduction to the analytical tools applied to determine particle size, morphology, and shape

* Common chemical approaches to drug system characterization

* A description of solid-state characterization of drug systems

* Drug release and permeation studies

* Toxicity and safety issues

* The interaction of drug particles with cells

Perfect for pharmaceutical chemists and engineers, as well as all other industry professionals and researchers who deal with drug delivery systems on a regular basis, Characterization of Pharmaceutical Nano- and Microsystems also belongs on bookshelves of interested students and faculty who interact with this topic.

Table of Content

1. Selecting a Particle Sizer for the Pharmaceutical Industry

Professor Maria Margarida Figuiredo (mmf@eq.uc.pt)

2. Spectroscopic methods in solid-state characterization

Professor Clare Strachan (clare.strachan@helsinki.fi)

3. Microfluidic analysis techniques for safety assessment of pharmaceutical nano- and microsystems

Dr Tiina Sikanen(tiina.sikanen@helsinki.fi)

4. In Vitro In Vivo Correlation for Pharmaceutical Nano and Microsystems

Prof. Vandana Patravale (vbp_muict@yahoo.co.in)

5. Characterization of Bioadhesion, Mucin-interactions and Mucosal Permeability of Pharmaceutical Nano- and Microsystems

Ellen Hagesaether, Marianne Hiorth and Prof Ingunn Tho (Ingunn.tho@farmasi.uio.no)

6. Cell-Nanoparticle Interactions: Toxicity and Safety Issues

Helder Santos (helder.santos@helsinki.fi)

7. Intestinal mucosal tissue models to validate functionalized nanosystems

Bruno Sarmento (bruno.sarmento@ineb.up.pt)

8. Biodistribution of polymeric, polysaccharide and metallic nanoparticles

Erem Bilensoy (eremino@hacettepe.edu.tr)

9. Opportunities and challenges of silicon-based nanoparticles for drug delivery and imaging

Jessica Rosenholm (jessica.rosenholm@abo.fi)

10. Statistical Analysis and Multidimensional Modelling in Research Osmo Antikainen (osmo.antikainen@helsinki.fi)

About the author

Leena Peltonen is Adjunct Professor in the Division of Pharmaceutical Chemistry and Technology at the University of Helsinki, Finland. She holds two master’s degrees, as well as a Ph D in Pharmacy that she obtained in 2001.