This book describes a unique class of secondary metabolites, the mono- and dimeric-naphthylisoquinoline alkaloids. They exclusively occur in lianas of the palaeotropical Ancistrocladaceae and Dioncophyllaceae plant families. Their unprecedented structures include stereogenic centers and rotationally hindered, and therefore stereogenic, axes. Extended recent investigations on six Ancistrocladus species from Asia, as reported in this contribution, shed light on their fascinating phytochemical productivity, with over 100 intriguing natural products. This high chemodiversity arises from a similarly unique biosynthesis from acetate-malonate units, following a novel polyketidic pathway to plant-derived isoquinoline alkaloids. Some of the compounds show most promising anti-parasitic activities. Additionally, strategies for the regio- and stereoselective total synthesis of the alkaloids, including the directed construction of the chiral axis, are also presented.
A. Douglas Kinghorn & Heinz Falk
Ancistrocladus Naphthylisoquinoline Alkaloids
Ancistrocladus Naphthylisoquinoline Alkaloids
Ngôn ngữ Anh ● định dạng PDF ● Trang 335 ● ISBN 9783031104572 ● Kích thước tập tin 13.4 MB ● Biên tập viên A. Douglas Kinghorn & Heinz Falk ● Nhà xuất bản Springer International Publishing ● Thành phố Cham ● Quốc gia CH ● Được phát hành 2023 ● Có thể tải xuống 24 tháng ● Tiền tệ EUR ● TÔI 8778561 ● Sao chép bảo vệ DRM xã hội