The book will benefit a reader with a background in physical sciences and applied mathematics interested in the mathematical models of genetic evolution. In the first chapter, we analyze several thought experiments based on a basic model of stochastic evolution of a single genomic site in the presence of the factors of random mutation, directional natural selection, and random genetic drift. In the second chapter, we present a more advanced theory for a large number of linked loci. In the third chapter, we include the effect of genetic recombination into account and find out the advantage of sexual reproduction for adaptation. These models are useful for the evolution of a broad range of asexual and sexual populations, including virus evolution in a host and a host population.
Igor M. Rouzine
One-Locus and Multi-Locus Theory and Recombination
One-Locus and Multi-Locus Theory and Recombination
语言 英语 ● 格式 EPUB ● 网页 181 ● ISBN 9783110608199 ● 文件大小 11.7 MB ● 出版者 De Gruyter ● 市 Berlin/Boston ● 发布时间 2020 ● 版 1 ● 下载 24 个月 ● 货币 EUR ● ID 7651553 ● 复制保护 Adobe DRM
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